introduction: colorectal carcinoma is a main health problem in many countries and the third common cancer in iran. this malignancy at present is the most curable carcinoma of gastrointestinal tract. variation in the expression of the proteins produced by p53, p21, p16, e-cadherin, and β-catenin genes have been noted in this malignancy and may be important in the prognosis and therapeutic respon...

Colorectal cancer is becoming more common and deadly in both men women nowadays. Although various treatment interventions are available including chemotherapy, surgery, radiation therapy hormonal therapy, they associated with some harmful effects. To avoid the risk factors these therapies, natural products could be used as one of most promising candidates for colorectal cancer. The their dietar...

background a considerable portion of gastrointestinal malignancies undergoes surgery without curative resection. this study was conducted to assess surgical outcome in patients with gastrointestinal cancers. methods we reviewed individuals with esophagus, stomach, colon and rectum cancers admitted for surgical treatment after initial preoperative evaluations. surgical outcome, stage of tumors a...

background there is evidence of a possible etiological role of human papillomaviruses (hpvs) in the development of colorectal cancer. loss of p53 tumor suppressor gene function has been found in many malignancies and it can occur in a variety of ways, including gene mutation and interaction with the e6 protein of oncogenic hpvs. the objective of this study was to determine the prevalence of hpv...

Background: Ligustrazine, active ingredients extracted from the natural herb Ligusticum Chuanxiong Hort, has promising anti-tumor properties on tumor cell lines. However, potential activity of ligustrazine colorectal cancer (CRC) cells and molecular mechanisms have not been elucidated. In this study, we explored critical functions SW480 CT26 at cellular levels.

The tumor suppressor adenomatous polyposis coli (APC) is mutated in sporadic and familial colorectal tumors. APC stimulates the activity of the Cdc42- and Rac1-specific guanine nucleotide exchange factor Asef and promotes the migration and invasion of colorectal tumor cells. Furthermore, Asef is overexpressed in colorectal tumors and is required for colorectal tumorigenesis. It is also known th...

PURPOSE To determine the role of gelatinase in the hepatic metastatic process of colorectal cancer, we correlated gelatinolytic activity in colorectal tumor tissue both to the presence of intravasated colorectal epithelial cells and to the formation of liver metastasis. EXPERIMENTAL DESIGN The gelatinolytic activity was analyzed in tumor tissue samples from 68 colorectal cancer patients by us...