The bacterial nutritional and stress alarmone ppGpp and its co-factor DksA directly bind RNA polymerase to regulate its activity at certain sigma70-dependent promoters. A number of promoters that are dependent on alternative sigma-factors function poorly in the absence of ppGpp. These include the Pseudomonas-derived sigma54-dependent Po promoter and several other sigma54-promoters, the transcri...

Alginate overproduction in Pseudomonas aeruginosa can be caused by the proteolysis of the anti-sigma factor MucA regulated by the AlgW protease. Here, we show that inactivation of MucD, an HtrA/DegP homolog and alginate regulator, can bypass AlgW, leading to an atypical proteolysis of MucA that is dependent on the MucP protease.

BACKGROUND Fibre treatment often produces gaseous symptoms which have been attributed to fermentation by colonic bacteria with increased gas production. Effects of fibre ingestion on intestinal gas flow are unexplored. AIMS We aimed to test the hypothesis that consumption of a high fibre diet retards gas transit. SUBJECTS Ten healthy volunteers participated. METHODS To investigate the eff...

hepatic inflammatory pseudotumor (ipt) is a rare non-neoplastic process of unknown etiology, generally following a benign inflammatory condition. it is often mistaken as an either primary or metastatic malignancy in imaging studies. we report a 48 year-old female with numerous target lesions (2-4 cm) seen on high resolution ultrasound, spiral ct scan, and mri in all liver lobes compatible with ...

background: the appropriate colon cleansing is a major determinant of quality of colonoscopy. the aim of this study was to compare the efficacy and tolerability of the morning (am) peg (polyethylene glycol) solution to previous-evening (pm) peg solution for the afternoon colonoscopy. methods: this comparative study compared the am to pm prep for afternoon outpatient colonoscopy. the subjects ra...

introduction: the objective of the present study is to investigate the relationship between the familial history of digestive system cancers and development of gastric cancer. methods: in this case-control study conducted in 2012, 84 patients with a definite diagnosis of gastric cancer, diagnosed using endoscopy and pathological study of biopsies, were compared with 84 people with the same age ...

background: the iron deficiency anemia (ida) is a common cause of referral to medical departments. chronic gastrointestinal (gi) blood loss is important cause of ida and also an alarming sign of serious underlying disease. the information concerning ideal evaluation of the gastrointestinal tract in patients with the ida is scant. we designed a prospective study to determine the frequency of gi ...

an 8-month-old female thoroughbred foal was presented showing signs of colic. the foal was anxious,exhibiting signs of abdominal pain and distention. the foal had tachycardia (120 beats/min), tachypnea (40breaths/min). blood samples obtained for haematologic and serum biochemistry analysis that showed a pcvof 30% and a tpp of 70 g/l. the peritoneal fluid analysis revealed a clear fluid with mil...