PURPOSE The use of replication-selective oncolytic adenoviruses is an emerging therapeutic approach for cancer, which thus far has not been employed for carcinoids. We therefore constructed Ad[CgA-E1A], a novel replication-selective oncolytic adenovirus, where the chromogranin A (CgA) promoter controls expression of the adenoviral E1A gene. EXPERIMENTAL DESIGN The Ad[CgA-E1A] virus was evalua...

Wounding stress is an effective strategy to increase the content of bioactive compounds in horticultural crops. Potato tubers subjected wounding accumulate chlorogenic acid (CGA) and CGA isomers (neo-CGA crypto-CGA), which are phenolics that prevent treat different chronic degenerative diseases. In this study, effects storage temperature (10 °C 20 for 168 h) on accumulation potatoes were evalua...

BACKGROUND To provide quality care to the growing number of older patients, primary care physicians (PCPs) will require support from geriatric specialists. Multidisciplinary comprehensive geriatric assessment (CGA) has been found to improve outcomes in older people. This study explored the contribution of CGA to the management of older patients by their PCPs; PCP attitudes to CGA; and PCP satis...

Chromogranin A (CgA) is transported restrictedly to secretory granules in neuroendocrine cells. In addition to pH-and Ca 2 +-dependent aggregation, CgA is known to bind to a number of vesicle matrix proteins. Because the binding-prone property of CgA with secretory proteins may be essential for its targeting to secretory granules, we screened its binding partner proteins using a yeast two-hybri...

Chromogranin A (CgA), a marker of neuroendocrine cells and an indicator for neuroendocrine differentiation, is associated with a poor prognosis when detected in tumor tissue, based on immunohistochemical techniques. We sought to determine whether it is possible to detect elevated serum CgA in patients with commonly occurring carcinomas of non-neuroendocrine origin. CgA was measured in both rand...

Chromogranin A (CgA), a neuroendocrine secretory protein, and its fragments are present in variable amounts in the blood of normal subjects and cancer patients. We investigated whether circulating CgA has a regulatory function in tumor biology and progression. Systemic administration of full-length CgA, but not of fragments lacking the C-terminal region, could reduce tumor growth in murine mode...

BACKGROUND Tumour marker measurement gives clinicians useful information for the follow-up and management of patients with neuroendocrine tumours (NETs). The currently used tumour markers for NETs are neuron-specific enolase (NSE) and chromogranin A (CgA). The clinical accuracy of these biomarkers depends on histotype and disease extent. CgA is thought to be the optimal marker for most NETs, as...

Chromogranin A (CGA) is the major soluble protein within secretory vesicles of chromaffin cells. A polyclonal antiserum was raised against bovine CGA and characterized in two-dimensional immunoblots. Cellular and subcellular distribution of CGA in bovine pancreatic islet was investigated by immunocytochemistry. At the light microscopic level, CGA-like immunoreactivity was found in the same cell...

Compressed compact genetic algorithm (cGA) is an algorithm that utilizes the compressed chromosome encoding and compact genetic algorithm (cGA). The advantage of cGA is to reduce the memory usage by representing population as a probability vector. In this paper, we analyze the performance in term of robustness of cGA. Since the compression and decompression strategy employ two parameters, which...