Because treatment with lithium salts may impair renal concentrating ability, we investigated the possibility of a direct effect of lithium ions on the permeability to water of the collecting duct epithelium. The coefficient of hydraulic conductivity (Lp) of isolated perfused rabbit cortical collecting tubules (CCT) was measured in the presence and absence of arginine-8-vasopressin (AVP), or 8-b...

The effect of bradykinin on changes in the chemical levels of myo-inositol polyphosphates in renal papillary collecting tubules was investigated. Myo-inositol phosphate mass was determined by means of an enzymatic, fluorometric assay. Bradykinin induced increases in myo-inositol mono-, bis-, and trisphosphate which were both time and concentration dependent. Furthermore, the magnitude of the ch...

Abstract In order to study kidney changes in, Tenualosa ilisha during migration from sea to the river, twenty mature T. ilisha specimens were collected from the Persian Gulf (42.7ppt salinity and 29.27°C temperature) and twenty specimens from Arvand River (2.3ppt salinity and 21.16°C temperature). Macroscopic observation indicated that the kidney was located retroperitoneal and attached to...

To address the question of insulin-like growth factor (IGF) I localization and synthesis in kidney, we used two complementary experimental approaches: immunohistochemistry of fixed paraffin-embedded rat kidney sections; and measurement of IGF I mRNA in isolated components of the rat nephron, using a highly sensitive and specific solution hybridization assay. Immunostainable IGF I was localized ...

Collecting duct carcinoma or Bellini duct carcinoma is a very rare variant of kidney carcinoma, characterized by an aggressive course and an extremely poor prognosis [1-4,5]. Unlike the more common variants of renal cell carcinoma that arise from the convoluted tubules of the renal cortex, this aggressive malignancy is derived from the renal medulla, possibly from the distal collecting ducts of...

A serine/threonine kinase Akt is a key mediator in various signaling pathways including regulation of renal tubular transport. In proximal tubules, Akt mediates insulin signaling via insulin receptor substrate 2 (IRS2) and stimulates sodium-bicarbonate cotransporter (NBCe1), resulting in increased sodium reabsorption. In insulin resistance, the IRS2 in kidney cortex is exceptionally preserved a...