نتایج جستجو برای: collagen scaffold

تعداد نتایج: 83412  

2017
Alireza Sadeghi-Avalshahr Samira Nokhasteh Amir Mahdi Molavi Mohammad Khorsand-Ghayeni Meysam Mahdavi-Shahri

The aim of this study is to investigate the applicability of poly(lactic-co-glycolic acid) (PLGA)/collagen composite scaffold for skin tissue engineering. PLGA and collagen were dissolved in HFIP as a common solvent and fibrous scaffolds were prepared by electrospinning method. The scaffolds were characterized by scanning electron microscopy (SEM), FTIR spectroscopy, mercury porosimetry, tensil...

Journal: :Tissue engineering. Part A 2011
Donna Phu Lindsay S Wray Robert V Warren Richard C Haskell Elizabeth J Orwin

Corneal blindness is a significant problem treated primarily by corneal transplants. Donor tissue supply is low, creating a growing need for an alternative. A tissue-engineered cornea made from patient-derived cells and biopolymer scaffold materials would be widely accessible to all patients and would alleviate the need for donor sources. Previous work in this lab led to a method for electrospi...

Journal: :Biomaterials 2011
Margit Kempf Yuki Miyamura Pei-Yun Liu Alice C-H Chen Hideki Nakamura Hiroshi Shimizu Yasuhiko Tabata Roy M Kimble James R McMillan

Biomaterial scaffolds are categorized into artificial or natural polymers, or combinations of the two. Artificial polymers often undergo serum protein adsorption, elicit foreign body and encapsulation immune responses post-implantation. Large pore bovine electrospun collagen I was therefore screened as a candidate for human keratinocyte and fibroblast cell scaffolds. Human HaCaT keratinocyte an...

2016
Ana M. Cortizo Graciela Ruderman Flavia N. Mazzini M. Silvina Molinuevo Ines G. Mogilner

Bone and cartilage regeneration can be improved by designing a functionalized biomaterial that includes bioactive drugs in a biocompatible and biodegradable scaffold. Based on our previous studies, we designed a vanadium-loaded collagen scaffold for osteochondral tissue engineering. Collagen-vanadium loaded scaffolds were characterized by SEM, FTIR, and permeability studies. Rat bone marrow pro...

Journal: :Tissue engineering. Part A 2013
Cevat Erisken Xin Zhang Kristen L Moffat William N Levine Helen H Lu

The diameter of collagen fibrils in connective tissues, such as tendons and ligaments is known to decrease upon injury or with age, leading to inferior biomechanical properties and poor healing capacity. This study tests the hypotheses that scaffold fiber diameter modulates the response of human tendon fibroblasts, and that diameter-dependent cell responses are analogous to those seen in health...

Journal: :Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 2008
May Jacobson Duretti Fufa Eduardo L Abreu Sherwin Kevy Martha M Murray

Platelets and erythrocytes are major components of wound provisional scaffolding. In this study, we hypothesized that the concentration of platelets and erythrocytes would significantly affect fibroblast-mediated contraction of three-dimensional scaffolds or the release of cytokines from the scaffold. To test this hypothesis, human anterior cruciate ligament fibroblasts were cultured in one of ...

2006
Juthamas RATANAVARAPORN Siriporn DAMRONGSAKKUL Neeracha SANCHAVANAKIT Tanom BANAPRASERT Sorada KANOKPANONT

Gelatin and collagen were used to produce the scaffold for fibroblast cell culture. The properties of scaffolds obtained from type A and type B gelatin were compared to scaffold obtained from collagen, which is widely used in skin substitute. Porous scaffolds were prepared by freeze drying and dehydrothermal (DHT) crosslinking method. DHT treatment time was performed at 24 and 48 h and the degr...

2013
James F Kirk Gregg Ritter Isaac Finger Dhyana Sankar Joseph D Reddy James D Talton Chandra Nataraj Sonoko Narisawa José Luis Millán Ronald R Cobb

Collagen scaffolds have been widely employed as a dermal equivalent to induce fibroblast infiltrations and dermal regeneration in the treatment of chronic wounds and diabetic foot ulcers. Cross-linking methods have been developed to address the disadvantages of the rapid degradation associated with collagen-based scaffolds. To eliminate the potential drawbacks associated with glutaraldehyde cro...

Journal: :Journal of biomaterials science. Polymer edition 2013
Wenda Zhou Matthew Blewitt Ashley Hobgood Rebecca Kuntz Willits

Extracellular matrix incorporated within a scaffold plays an important role in assisting cell behavior in neural tissue engineering. In this study, we investigated how the concentration of fibronectin (FN) affected neurite growth when incorporated within a synthetic polymer gel made of poly(ethylene glycol) (PEG) or a natural polymer gel of collagen I. Mechanical and chemical properties of the ...

2008
M. Itoh A. Shimazu

For reconstruction and regeneration of hard tissues, scaffold biomaterials with large size pores and high porosity are important, in addition to their roles as supporting frames. To develop a new biodegradable scaffold biomaterial, CO3Ap, which has crystallinity and a chemical composition similar to bone, was synthesized at pH 7.4 and 60 C. Then, the CO3Ap was mixed with a neutralized collagen ...

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