نتایج جستجو برای: collagen ix
تعداد نتایج: 79958 فیلتر نتایج به سال:
Two collagen type IX gene polymorphisms that introduce a tryptophan residue into the protein's triple-helical domain have been linked to an increased risk of lumbar disc disease. To determine whether a particular subset of symptomatic lumbar disease is specifically associated with these polymorphisms, we performed a prospective case-control study of 107 patients who underwent surgery of the lum...
چکیده سابقه و هدف فاکتور IX طی بلوغ خود در کبد، نیازمند کربوکسیلاسیون اسیدآمینه‌های گلوتامیک در ناحیه گلا می‌باشد که در ترشح و فعالیت آن نقش دارد. با توجه به ناکارآمدی سیستم بیانی پستانداران در ترشح و گاماکربوکسیلاسیون کامل فاکتورهای انعقادی نوترکیب و فعالیت بالاتر آنزیم گاماکربوکسیلاز در سامانه دروزوفیلا (S2)، مطالعه حاضر با هدف بررسی قابلیت این سامانه در گاماکربوکسیلاسیون و لذا ترشح و فعالیت...
Carbonic anhydrase (CA) IX is a transmembrane isozyme of CAs that catalyzes reversible hydration of CO(2). While it is known that CA IX is distributed in human embryonic chondrocytes, its role in chondrocyte differentiation has not been reported. In the present study, we found that Car9 mRNA and CA IX were expressed in proliferating but not hypertrophic chondrocytes. Next, we examined the role ...
Otosclerosis is a frequent cause of nonsyndromic hearing loss which affects exclusively the human temporal bone. Various etiopathogenetic hypotheses have been proposed. The major hypotheses considered are genetic factors, immunologic factors and viral infection. Since the familial incidence of otosclerosis is known a recent genetic analysis has given evidence of three otosclerosis genes (OTSC1-...
TWO new disulfide-bonded collagenous pepsin-&rived fragments have been isolated from chick embryo tendons. These fragments represent less than 0.5% of the pepsin-extractable collagen. We purified 10and 16-kDa reduced fragments derived, respectively, from 32and 46-kDa disulfide-bonded fragments. Unique tryptic peptide maps were obtained for each fragment. Although these collagenous fragments dif...
The platelet collagen receptor, glycoprotein VI (GPVI), and GPIb-IX-V, which binds von Willebrand factor, initiate platelet aggregation at low or high shear stress, respectively. We recently reported that positively charged, membrane-proximal sequences within cytoplasmic domains of GPIb and GPV of GPIbIX-V bind calmodulin. We now show that GPVI also binds calmodulin as follows—(1) calmodulincoi...
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