Inflammatory processes play a critical role in the pathogenesis of the neurodegenerative disorders and are associated with cognitive impairments. Nonsteroidal anti-inflammatory drugs (NSAIDs) and nitric oxide releasing NSAIDs are reported to be effective in reducing the risk of developing AD or cognitive impairments. Present experiments were performed to study the possible effect of nitro napro...

Introduction Prior mechanistic studies in rodents showed decreased levels of the pivotal mitochondrial metabolite acetyl-L-carnitine (LAC) relation to cognitive deficits and depressive-like behavior (Neuron 2017, 10.1016/j.neuron.2017.09.020, PNAS 2013, 10.1073/pnas.1216100110), providing basis for current translational study. Objectives The main objective this work was ascertain role specific ...

Although the gross deficits of diseases of the brain have been extensively characterized, few studies have examined their associated cognitive impairments. Interest has focused recently on the language and cognitive impairments that develop following encephalitis. The symptoms of impairments following the disease were determined mainly by examining hospital records of those previously admitted ...

Although much is known about the relationship between neuropsychiatric problems and the severity of cognitive impairments, relatively little is known about the association with specific cognitive impairments. The aim of this study was to determine whether specific cognitive impairments are predictive of neuropsychiatric problems. One hundred twenty-six patients were evaluated every 6 months for...

Chronic fatigue syndrome (CFS) is characterized by fatigue, sleep dysfunction, and cognitive deficits (Fukuda et al., 1994). Research surrounding cognitive functioning among patients with CFS has found difficulty with memory, attention, and information processing. A similar disorder, postural tachycardia syndrome (POTS), is characterized by increased heart rate, fatigue, and mental cloudiness (...

Inflammatory processes play a critical role in the pathogenesis of the neurodegenerative disorders and are associated with cognitive impairments. Nonsteroidal anti-inflammatory drugs (NSAIDs) and nitric oxide releasing NSAIDs are reported to be effective in reducing the risk of developing AD or cognitive impairments. Present experiments were performed to study the possible effect of nitro napro...

BACKGROUND To investigate the association between isolated and combined affective and cognitive impairments with functional outcomes and discharge destination in older patients admitted to rehabilitation after a hip fracture. METHODS Prospective study in 612 community-dwelling patients aged 65 years and over, admitted to rehabilitation after surgery for hip fracture. Information on socio-demo...

OBJECTIVE Preterm birth has been associated with an increased risk of attention-deficit/hyperactivity disorder (ADHD)-like symptoms and cognitive impairments similar to those seen in ADHD, including attention and inhibitory control difficulties. Yet data on direct comparisons across ADHD and preterm birth on cognitive-neurophysiological measures are limited. METHOD We directly compared 186 pr...

PURPOSE/OBJECTIVES To review the domains of cognitive function and their corresponding neuroanatomic structures as well as present current evidence for neurotoxicity associated with specific chemotherapeutic agents and potential mechanisms for chemotherapy-induced cognitive impairments. DATA SOURCES Published research articles, review articles, and textbooks. DATA SYNTHESIS Chemotherapy doe...