BACKGROUND Disseminated coccidioidomycosis (which is caused by the endemic fungi of the genus Coccidioides) can be a life-threatening systemic fungal infection. Although conventional antifungal therapies have activity against Coccidioides, the disease can be refractory to standard therapies. Drug-associated toxicities also may limit the clinical utility of the standard antifungal drugs. In addi...

Coccidioides spp. (immitis and posadasii) are the causative agents of human coccidioidomycosis. In this study, we developed a novel system to overexpress coccidioidal proteins in a nonpathogenic fungus, Uncinocarpus reesii, which is closely related to Coccidioides. A promoter derived from the heat shock protein gene (HSP60) of Coccidioides posadasii was used to control the transcription of the ...

The chief obstacles to the study of the parasitic or in vivo form (spherule) of Coccidioides immitis grown in synthetic media have been: (1) separating spherules from hyphae, (2) obtaining rupture of the majority of the spherules, and (3) failure of the endospores to separate from the spherule matrix. Growth of spherules in a chemically defined liquid medium composed of glucose, ammo(liberated ...

Egeberg, Roger O. (University of Southern California, Los Angeles), Ann F. Elconin, and Margaret C. Egeberg. Effect of salinity and temperature on Coccidioides immitis and three antagonistic soil saprophytes. J. Bacteriol. 88:473-476. 1964.-Experiments exploring the factors which determine the ability of Coccidioides immitis to survive and reproduce in the soil in situ are described and discuss...

The in vitro activity of voriconazole was compared to those of itraconazole and amphotericin B against the mold forms of 304 isolates of three dimorphic fungi, Blastomyces dermatitidis, Coccidioides immitis, and Histoplasma capsulatum. MICs were determined by a broth microdilution adaptation of the National Committee for Clinical Laboratory Standards M27-A procedure. RPMI 1640 medium was used f...