نتایج جستجو برای: coagulation pathway

تعداد نتایج: 358621  

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2014
Travis J Gould Trang T Vu Laura L Swystun Dhruva J Dwivedi Safiah H C Mai Jeffrey I Weitz Patricia C Liaw

OBJECTIVE Activation of neutrophils by microbial or inflammatory stimuli results in the release of neutrophil extracellular traps (NETs) that are composed of DNA, histones, and antimicrobial proteins. In purified systems, cell-free DNA (CFDNA) activates the intrinsic pathway of coagulation, whereas histones promote thrombin generation through platelet-dependent mechanisms. However, the overall ...

Journal: :Arteriosclerosis, Thrombosis, and Vascular Biology 2004

Journal: :Arteriosclerosis, Thrombosis, and Vascular Biology 2005

2017
Zhi Liu Jing Huang Qi Zhong Yanling She Ruimin Ou Cheng Li Rui Chen Mengdong Yao Qing Zhang Shuang Liu

The present study aimed to reveal the molecular mechanisms of multiple myeloma (MM) and monoclonal gammopathy of undetermined significance (MGUS). This was a secondary study on microarray dataset GSE80608, downloaded from the Gene Expression Omnibus database, which included 10 control samples, 10 MGUS samples and 10 MM samples. Differentially expressed genes (DEGs) were identified between contr...

Journal: :Blood 1977
R Radcliffe A Bagdasarian R Colman Y Nemerson

During the early events of coagulation of human blood by the intrinsic pathway, factor XII is activated to a form which can activate factor XI, and is proteolytically fragmented to smaller species (30,000 daltons and 70,000 daltons) which have lost most of the ability to activate factor XI but which can activate prekallikrein rapidly. The effect of these fragments on factor VII was studied. It ...

2017
Jiong-Wei Wang Ya-Nan Zhang Siu Kwan Sze Sander M van de Weg Flora Vernooij Arjan H Schoneveld Sock-Hwee Tan Henri H Versteeg Leo Timmers Carolyn S P Lam Dominique P V de Kleijn

Plasma extracellular vesicles (EVs) are lipid membrane vesicles involved in several biological processes including coagulation. Both coagulation and lipid metabolism are strongly associated with cardiovascular events. Lowering very-low- and low-density lipoprotein ((V)LDL) particles via dextran sulphate LDL apheresis also removes coagulation proteins. It remains unknown, however, how coagulatio...

2016
Nandini Nair Enrique Gongora

Introduction Up regulation of coagulation factors is a less understood phenomenon in congestive heart failure. Existing literature supports the fact that levels of von Willebrand factor, fibrinogen, ICAM, PECAM, P-selectin, d-dimer, fibrinogen, vascular cell adhesion molecules and platelet aggregation are significantly elevated in congestive heart failure [1-8]. The most frequently noted compli...

Journal: :Hamostaseologie 2010
M Levi

Critically ill patients often have systemic activation of both inflammation and coagulation. Increasing evidence points to an extensive cross-talk between these two systems, whereby inflammation not only leads to activation of coagulation, but coagulation also considerably affects inflammatory activity. The intricate relationship between inflammation and coagulation may have major consequences ...

2010
Monika E Gorczyca Bernd Jilma Christoph Male Sylvia Reitter James C Gilbert Ingrid Pabinger

Background Hemophilia A and B are disorders resulting from a deficiency in factor VIII (FVIII), and factor IX (FIX), respectively. Tissue Factor (TF) is a key component of the extrinsic pathway and plays a role in the coagulation defect of hemophilic blood. Neutralizing the activity of TFPI represents a promising treatment concept in patients with hereditary or acquired hemophilia. ARC19499 is ...

2005
ROBERT W. COLMAN

Intravascular coagulation (IVC) was evaluated in 19 patients with type II and 11 with type IV hyperlipoproteinemia before and after clofibrate therapy by measurement of soluble fibrin complexes (SFC) in plasma; fibrinolysis was estimated by quantitation of fibrin (ogen) degradation products in serum. Untreated type II and type IV patients had increased SFC (P < 0.01). The former also had activa...

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