Die nachhaltige Abscheidung und Umwandlung von Kohlendioxid (CO2) ist ein Schlüssel für das Erreichen einer kreislauforientierten Kohlenstoffwirtschaft. Bioelektrokatalyse verspricht, dieses Ziel zu erreichen. funktionale Integration CO2-fixierenden Enzymen in Materialien zur Elektrodenfunktionalisierung die Elektrosynthese stereochemisch komplexer Moleküle muss jedoch erst noch demonstriert we...

Objective(s): Staphylococcus aureus is an important bacterial pathogen responsible for a variety numbers of nosocomial and community acquired infections. Biofilm formation is regarded as an important factor in the establishment of S. aureus infection. The contribution of the genetic background of S. aureus to biofilm formation is poorly understood. The aim of the present work was to genotype S....

Abstract Hydroxycinnamoyl shikimates were reported in 2005 to be intermediates monolignol biosynthesis. 3-Hydroxylation of p -coumarate, originally thought occur via coumarate 3-hydroxylase (C3H) from -coumaric acid or its CoA thioester, was revealed the action coumaroyl shikimate 3?-hydroxylase (C3?H) utilizing -coumaroyl as substrate, itself derived -coumaroyl-CoA hydroxycinnamoyl-CoA: hydrox...

background: nephrotic syndrome is a disorder that leads to hyperlipidemia. l-carnitine and genistein can effect on lipid metabolism and the syndrome. in the present study, we have delved into the separate and the twin-effects of l-carnitine and genistein on the gene expressions of hmg-coa reductase and ldl receptor in experimental nephrotic syndrome. methods: in this controlled experimental stu...

The activation of pyruvate dehydrogenasea kinase activity by CoA esters has been further characterized. Half-maximal activation of kinase activity was achieved with about 1.0 microM acetyl-CoA after a 20-s preincubation in the presence of NADH. More than 80% of the acetyl-CoA was consumed during this period in acetylating sites in the pyruvate dehydrogenase complex as a result of the transacety...

metabolic myopathies are genetically inherited disorders of muscle energy production that result in skeletal muscle dysfunction. they are a large group of diseases with diverse inborn errors of metabolism, in particular muscle energy production, and including disorders of glycogen (lysosomal and non-lysosomal glycogenoses), lipid (disorders of fatty acid b-oxidation, primary carnitine deficienc...

It is shown that acyl-CoA binding protein (ACBP), in contrast with fatty acid binding protein (FABP), stimulates the synthesis of long-chain acyl-CoA esters by mitochondria. ACBP effectively opposes the product feedback inhibition of the long-chain acyl-CoA synthetase by sequestration of the synthesized acyl-CoA esters. Feedback inhibition of microsomal long-chain acyl-CoA synthesis could not b...

Growth on acetate or other acetyl-CoA-generating substrates as a sole source of carbon requires an anaplerotic pathway for the conversion of acetyl-CoA into cellular building blocks. Haloarchaea (class Halobacteria) possess two different anaplerotic pathways, the classical glyoxylate cycle and the novel methylaspartate cycle. The methylaspartate cycle was discovered in Haloarcula spp. and opera...