Glycogen synthase kinase (GSK-3) is a key enzyme in multiple cell processes. Since many pharmacological compounds that have effects on common metabolic pathways may have uses in many different diseases, we review here the possible involvement of glycogen synthase kinase 3 in diabetes, cancer and CNS diseases. Moreover, diabetes has recently been strongly linked to CNS diseases such as schizophr...

Recently, a rising interest is given to neuroimmune communication in physiological and neuropathological conditions. Meningeal immunity complex immune environment housing different types of cells. Here, we focus on meningeal T cells, possibly the most explored aspect neuro-immune cell interactions. Emerging data have shown that cells play crucial role pathogenesis several neurodegenerative diso...

The present report discusses the immune and clearance system of central nervous (CNS) in terms its anatomical, physiological, biochemical properties. There is now a growing body evidence that progressive dysfunction meningeal lymphatic should be considered as risk factor for aging-related brain disorders. In addition, activity lymphatics may alter access CSF-carried neuromodulators to parenchym...

Certain cells within the CNS, microglial cells and perivascular macrophages, develop from hemopoietic myelomonocytic lineage progenitors in the bone marrow (BM). Such BM-derived cells function as CNS APC during the development of T cell-mediated paralytic inflammation in diseases such as experimental autoimmune encephalomyelitis and multiple sclerosis. We used a novel, interspecies, rat-into-mo...

Meningoencephalitis of unknown origin (MUO) is one the most common inflammatory diseases central nervous system (CNS). The study evaluates possible increase and potential role acute phase proteins (APPs) other serum parameters as biomarkers predicting short-term outcome dogs with meningoencephalitis (MUO). A retrospective cohort was designed. APP profile markers systemic inflammation forty-eigh...