A series of 5,7-dibromoisatin semicarbazones have been synthesized in good yield, involving aryl urea and aryl semicarbazide formation. The structures of the synthesized compounds were confirmed on the basis of their spectral data. All the compounds were evaluated for anticonvulsant and CNS depressant activities. Anticonvulsant activity was determined after intraperitoneal (i.p.) administration...

A variety of names for Kalanchoe pinnata include wondering the world, miraculous plant, and Pattharchatta. It features tall cylindrical stems, meaty, deeply scalloped dark green leaves, pendulous scarlet bell-shaped blooms that are trimmed. is well-known in scientific community to display a wide spectrum pharmacological actions treatment most severe human disorders. The studies reviewed discuss...

Physical and psychic dependence on opioids and CNS depressants in rodents were examined using the drug-admixed food (DAF) method. A comparison of several methods for developing physical dependence on opioids was made. The DAF method has the advantage of rapidly inducing a high degree of physical dependence without causing morbidity or mortality. When morphine-dependent rats were pretreated with...

Clobazam, one of the newer benzodiazepines, is now used extensively as first add on therapy in focal epilepsy. A 67-year-old diabetic and hypertensive gentleman with a history frontal contusion year ago, presented clustering seizures. He was started clobazam 20 mg, levetiracetam 1000 mg/day. Recurrence seizures prompted dose escalation to 40 The patient developed hepatic encephalopathy his deco...

Triazolo-thiadiazines 4a–f and triazolo-tetrazines 8g–l were prepared from reaction of 3-(4-amino-5-mercapto-4H-1,2,4-triazol-3-yl)-2H-chromen-2-one with the respective hydrazonoyl halides 2a–f 2g–l. Moreover, aminomercaptotriazole derivative phenacyl bromide ethyl 2-chloro-3-oxobutanoate followed by coupling products benzenediazonium chloride yielded corresponding 4f 8g, respectively. All newl...

Isatin, also known as 1H-Indole-2, 3-Dione, is an eight-carbon containing endogenous compound found in nature. Erdmann and Laurent synthesized isatin 1840, before it was discovered It versatile distributed tissues body fluids. Isatins have been detected mammalian tissue, their function a biochemical process modulator has the focus of many debates. The moiety shows some important chemical reacti...

BACKGROUND Substituted 1,3,4-oxadiazoles are of considerable pharmaceutical interest. 2,5-Substituted diphenyl-1,3,4-oxadiazoles are associated with diverse biological activities by the virtue of -N = C-O- grouping. In the view of wide range of biological properties associated with 1,3,4-oxadiazole, we have synthesized substituted derivatives of 1,3,4-oxadiazole (XIII-XXII), a versatile hydroph...

Peritonitis remains an important cause of morbidity and technique failure in peritoneal dialysis (PD). Conventional peritoneal dialysate fluids (PDF) inhibit peritoneal leukocyte function in vitro and may thus adversely affect the immune response to peritonitis. New PDF have been designed with neutral pH, low glucose degradation product (GDP) contents, and bicarbonate as buffer. The present int...