Cyanine borate (R(Ph)3B-; R alkyl) salts dissolved in non-polar solvents exist predominantly as ion pairs. Irradiation of the ion pair with visible light absorbed by the cyanine leads to formation of a locally excited singlet state of the dye. The singlet excited cyanine in the ion pair is capable of oxidizing the borate anion to the boranyl radical (R(Ph)3B.) The rate constant for this electro...

The activation and functionalization of carbon–fluorine bonds represent a significant synthetic challenge, given the high thermodynamic barrier to C–F bond cleavage. Stoichiometric hydridoborane-me...

Treatment of DNA containing AP sites with either T4 UV endonuclease or with E. coli endonuclease III followed by a human class II AP endonuclease releases a putative beta-elimination product. This result suggests that both the T4 endonuclease and E. coli endonuclease III class I AP endonucleases catalyze phosphodiester bond cleavage via a lyase- rather than a hydrolase mechanism. Indeed, we hav...

Carbon-carbon bond cleavage/functionalization is synthetically valuable, and selective carbonyl-C(sp3 ) bond cleavage/alkynylation presents a new perspective in constructing ynamides, ynoates, and ynones. Reported here is the first alkoxyl-radical-enabled carbonyl-C(sp3 ) bond cleavage/alkynylation reaction by photoredox catalysis. The use of novel cyclic iodine(III) reagents are essential for ...

We show here that non-thermal atmospheric plasma induces the cleavage of N–H bond NH 3 to form aminium radicals, which then add onto ethylene ethylamine in 17% yield.

In the title compound, C(18)H(22)N(4)O, the C=N and C-N bond lengths in the CN(3) unit are 1.3179 (11), 1.3551 (11) and 1.3737 (11) Å, indicating double- and single-bond character, respectively. The N-C-N angles are 115.91 (8), 118.20 (8) and 125.69 (8), showing a deviation of the CN(3) plane from an ideal trigonal-planar geometry. The bonds between the N atoms and the terminal C-methyl groups ...

INTRODUCTION Cleavage of aggrecan within the interglobular domain (IGD) at the GluAla bond has been attributed to the protease “aggrecanase” (1,2). In addition to this cleavage site, aggrecanase has been shown to cleave within the C-terminal region of aggrecan between G2 and G3 (3). The core protein of aggrecan is highly glycosylated with regions rich in both keratan sulfate (KS) and chondroiti...

The peroxo dizinc Zn(2)O(2) complex Q coordinated by imidazole and carboxylate groups for each Zn center has been designed to model the hydroxylase component of methane monooxygenase (MMO) enzyme, on the basis of the experimentally available structure information of enzyme with divalent zinc ion and the MMO with Fe(2)O(2) core. The reaction mechanism for the hydroxylation of methane and its der...