Introduction: The African Americans’ health paradox can be defined as better subjective held of American individuals compared to White individuals, despite their higher objective and medical adversities such chronic conditions (CMCs). This phenomenon depicts relative resilience (advantage). However, most the existing literature on this topic is limited studies comparing Americans Whites. There ...

The mi locus of mice encodes a member of the basic-helix-loop-helix-leucine zipper (bHLH-Zip) protein family of transcription factors (hereafter called MITF). Cultured mast cells of mi/mi genotype (mi/mi CMCs) did not normally respond to stem cell factor (SCF), a ligand for the c-kit receptor tyrosine kinase. The poor response of mi/mi CMCs to SCF was attributed to the deficient expression of c...

AIMS As an alternative strategy to obtain large amounts of ginseng extract with high yield of ginsenosides, we have utilized culture of cambial meristematic cells (CMCs) from wild ginseng. The anti-tumor effects of methanol extract of ginseng CMCs (MEGC) and their action mechanisms were investigated. MAIN METHODS Mice were intraperitoneally administered with MEGC, and we explored NK cell acti...

We established a QT interval assessment system that uses human embryonic stem cell-derived cardiomyocyte clusters (hES-CMCs) in which the field potential duration (FPD) or corrected FPD (FPDc) was measured as an indicator of drug-induced QT interval prolongation. To investigate the applicability of the hES-CMC system to drug safety assessment, we investigated short-term variability in FPDc (STV...

Survivors of childhood acute lymphoblastic leukemia (ALL) are at risk for late effects of cancer therapy. Five-year ALL survivors (< 21 years at diagnosis; n = 5760 eligible, 4151 participants), diagnosed from 1970 to 1986 were compared with the general population and a sibling cohort (n = 3899). Cumulative mortality of 5760 5-year survivors was 13% at 25 years from diagnosis. Recurrent ALL (n ...

Native rhizobia are ideal for use as commercial legume inoculants. The characteristics of the carrier used to store the inoculants are important for the survival and symbiotic potential of the rhizobia. The objective of this study was to investigate the effects of peat (PEAT), perlite sugarcane bagasse (PSB), carboxymethyl cellulose plus starch (CMCS), and yeast extract mannitol supplemented wi...

Size selection via filtration offers an antigen-independent approach for the enrichment of rare cell populations in blood of cancer patients. We evaluated the performance of a novel approach for multiplex rare cell detection in blood samples from metastatic breast (n = 19) and lung cancer patients (n = 21), and healthy controls (n = 30) using an automated microfluidic filtration and multiplex i...

3 1 Synthèse des Travaux 5 1.1 Segmentation Statistique d’Images . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 1.2 Détection et Reconnaissance de Formes 2D . . . . . . . . . . . . . . . . . . . . . . . . 9 1.3 Plan du manuscript . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11 2 Segmentation Statistique d’Images 13 2.1 Segmentation non supervisée d’im...

TO THE EDITOR Metastatic melanoma patients harboring a BRAF gene mutation on codon 600 can be treated with targeted therapies (Flaherty, 2012). Depending on the content of tumor cells and on the analytical sensitivity, BRAF mutations are found in 50–70% of metastatic melanoma patients (Davies et al., 2002). Around 80% display a valineto-glutamic acid substitution (V600E) and B16% harbor a valin...

Macrophages exhibit phenotypic plasticity, as they have the ability to switch their functional phenotypes during inflammation and recovery. Simultaneously, the mechanical environment actively changes. However, how these dynamic alterations affect the macrophage phenotype is unknown. Here, we observed that the extracellular matrix (ECM) constructed by AKAP12+ colon mesenchymal cells (CMCs) gener...