Introduction Clonidine (Fig. 1), an imidazoline derivative, is a centrally acting hypotensive agent but its use is being explored in a number of other indications such as anesthesia and the management of opiate with drawl (1). Clonidine belongs to a class of drugs called central alpha-adrenergic agonists. Clonidine has been in clinical use for over 40 years, which is used to treat hypertensive ...

Adjuvant to local anesthetics have been tried to enhance analgesic profile. Opioids prolong analgesia but have unfavorable side effect profile. So search for non-opioid with comparable analgesic duration and minimal side effect continues. Hence our study aims to compare Buprenorphine; an opioid similar in structure to morphine but approx. 33 times more potent, to a novel drug Clonidine; an imid...

Clonidine is reported to inhibit the az-adrenoceptor mediated pinnal reflex in mice (3). Clonidine produces its effect by acting as an oc2-adrenergic autoreceptor agonist (1). As such, clonidine is also agonist for presynaptic histamine Hz-receptors (8). To test whether the clonidine-induced inhibition of the pinnal reflex is mediated through adrenergic and/or histaminergic system, the interact...

An endogenous substance in brain, clonidine-displacing substance, binds to the same receptor populations as clonidine and is biologically active. Since receptor binding sites can be modeled by using specific antiligand antibodies, we tested the hypothesis that polyclonal antibodies raised in rat and rabbit against the clonidine analog p-aminoclonidine coupled to hemocyanin would recognize compo...

The effects of clonidine on substance P (SP) binding was investigated using rat brain and spinal cord membrane preparations preincubated with various concentrations of clonidine. [3H]SP specific binding in the spinal cord was significantly decreased with 10(-4) M clonidine, but no effect on binding was seen in the brain. Scatchard analysis of SP binding indicated that Bmax was significantly dep...

noradrenaline release.8.9 While clonidine and the opiates have similar effects on the locus coeruleus, clonidine appears to exert specific effects through non-opiate, alpha-2 adrenergic receptors. 6, These data suggested that the opiate-withdrawal syndrome is due to increased noradrenergic neuronal activity in areas such as the locus coeruleus which are regulated both by alpha-2 adrenergic and ...