Detoxification, the initial step in the treatment of opiate dependence (Freedman, 1980) has been facing difficulties in our country as the widely used drug methadone is not available. Earlier practices were either abrupt withdrawal or gradual tapering of the dose of the opiate to which the individual was dependent. Recently clonidine has been used with success for detoxification and treatment o...

I was interested to read the paper entitled “Effects of clonidine premedication upon postoperative shivering and recovery time in opium addicted and non-addicted patients by elective leg fracture surgeries” (1). I note that the authors administered vitamin C tablet as placebo for clonidine. Noteworthy, earlier animal studies have suggested that there is a close relationship between recovery fro...

The specific binding to platelet membranes (B~,) of 3H-clonidine, an alpha-2 agonist, and 3H-yohimbine, an alpha-2 antagonist, was measured in nine drug-free male schizophrenic patients and repeated after 2 weeks of chlorpromazine (CPZ) treatment. Patients with a lower pretreatment B,~,~ for 3H-clonidine showed a significantly smaller change in B~,~ after treatment, less improvement in their cl...

BACKGROUND In human cirrhosis, adrenergic hyperfunction causes proximal tubular fluid retention and contributes to diuretic-resistant ascites, and clonidine, a sympatholytic drug, improves natriuresis in difficult-to-treat ascites. AIM To compare clonidine (aspecific α2-adrenoceptor agonist) to SSP-002021R (prodrug of guanfacine, specific α2A-receptor agonist), both associated with diuretics,...

Pain is an unpleasant sensory perception warning of actual or impending tissue damage. Pain serves a vital physiological role, however, severe and uncontrolled pain in the peri-operative setting can adversely affect outcome from surgery and lead to chronic pain. Multiple neurochemical and receptor processes are involved in pain perception but the role of pro-inflammatory cytokines and adrenergi...

Noradrenaline is implicated in the modulation of attention and arousal, but the neuroanatomical basis of this effect in humans is unknown. A previous functional neuroimaging study failed to find clear effects of clonidine (alpha2 adrenoceptor agonist) on activity of brain regions implicated in attention. Therefore, we now investigate whether clonidine affects the functional integration of a neu...

An intense but task-irrelevant auditory accessory stimulus that is presented almost simultaneously with a visual imperative stimulus can reduce reaction times (RTs) to that stimulus. The information-processing locus and neural underpinnings underlying this phasic alerting effect are still poorly understood. The authors investigated a possible noradrenergic or cholinergic basis of the accessory ...

In this study, geometrical optimizations of Clonidine Drug were carried out with the HF/6-31g basissets .Then, drug was put covalently to carbon nanocone with (5, 1) structure and a length of 150A. Weuse chem Office software and hyper chem at the end data will be presented as tables and Figs.Simulation was done in MM+, AMBER and OPLS force fields by Monte Carlo method. Threeimportant energy par...

PURPOSE Clonidine may help prevent cardiac complications in patients undergoing non-cardiac surgery and receiving chronic beta-blocker therapy. We conducted a multicentre pilot randomized trial to estimate recruitment rates for a full-scale trial and to assess the safety and tolerability of combining clonidine with chronic beta-blockade. METHODS Patients who were at elevated perioperative car...

Dexmedetomidine is a new alpha2-agonist that received FDA approval in 1999 for use as a short-term (less than 24 h) sedativeanalgesic in the intensive care unit. The use of alpha2-agonists as anesthetics is not new since many alpha2-agonists are used in veterinary medecine to induce anesthesia. Clonidine, the prototype of alpha2agonists, has been synthesized in early 1970’s for its use as nasal...