Dear Editor, Propriospinal myoclonus (PSM) is characterized by jerks arising in axial muscles that spread to more caudal and rostral segments along propriospinal pathways. PSM at sleep onset is a subtype of PSM that occurs during the sleep–awake transition and causes severe sleep-onset insomnia.1 Previous case reports have focused on the etiology and mechanism of PSM, but have not evaluated tre...

Benzodiazepines possess a wide spectrum of valuable pharmacological effects and are among the leading drugs, commonly prescribed ones for various pathologies. Herein we describe continuous flow synthesis six benzodiazepines from aminobenzophenones: diazepam, fludiazepam, nordazepam, nitrazepam, clonazepam, oxazepam.

Acute interictal psychotic attacks during withdrawal of medication are described in two patients with temporal lobe epilepsy submitted to depth EEG study with a view to surgical treatment. The patients were on chronic treatment with clonazepam associated in one with phenobarbitone and in the other with phenobarbitone plus carbamazepine. Our observations suggest that the acute withdrawal of clon...

Offidani and colleagues1 gathered data through 2012 on published, controlled, and direct comparisons between benzodiazepines and antidepressants for anxiety disorders but were hindered, they said, by a “paucity of studies.” Their review encompassed 22 studies, 18 of which compared TCAs, such as amitriptyline, clomipramine, or imipramine, with benzodiazepines. Of the remaining studies, 3 compare...

Offidani and colleagues1 gathered data through 2012 on published, controlled, and direct comparisons between benzodiazepines and antidepressants for anxiety disorders but were hindered, they said, by a “paucity of studies.” Their review encompassed 22 studies, 18 of which compared TCAs, such as amitriptyline, clomipramine, or imipramine, with benzodiazepines. Of the remaining studies, 3 compare...

Oxytetracycline (OTC) is one of the broad-spectrum antibiotics widely used for treatment fish-farm infection. Considering that behavior directly related to reproduction, individual fitness, and survival, it important evaluate impact on behavioral repertoire in fish. Zebrafish (Danio rerio) presents a well-described reliably demonstrate complex responses chemical compound exposure. This work aim...

OBJECTIVE Therapeutic approaches for benzodiazepine (BZD) dependence in patients in methadone maintenance treatment (MMT) have met with limited success. Clonazepam detoxification (CDTX) and clonazepam maintenance treatment (CMT) were compared in an open, clinical naturalistic study on such patients. METHODS Benzodiazepine dependent patients substituted their BZD of abuse for clonazepam and we...

A percepção dolorosa, avaliada funcionalmente através do sistema analgésico endógeno, reflete a atividade nociceptivo, o qual depende nível de excitabilidade nervoso, portanto, procura vias e formas que reduzam deste tornou-se uma preocupação humana para assim aliviar da dor. Objetivo: Determinar limiar excitação nociceptivo em animais (camundongos) submetidos tratamento com diferentes doses cl...