Trichotillomania is a psychiatric condition characterized by compulsive hair pulling. Three interventions have been studied in the treatment of trichotillomania: habit-reversal therapy (HRT) and pharmacotherapy with either selective-serotonin reuptake inhibitors (SSRI) or clomipramine. This systematic review compared the efficacy of these interventions in blinded, randomized clinical trials. Th...

Obsessive compulsive disorder (OCD) is a psychiatric condition defined by intrusive thoughts (obsessions) associated with compensatory and repetitive behaviour (compulsions). However, advancement in our understanding of this disorder has been hampered by the absence of effective animal models and correspondingly analysis of the physiological changes that may be present in these models. To addre...

T he conventional pathophysiological view of the mechanism of neurocardiogenic syncope involves the activation of peripheral baroreceptors, as occurs in the Bezold-Jarisch reflex, in which there is a reflex withdrawal of sympathetic tone and an increase in parasympathetic tone. The result of these changes is a dramatic fall in blood pressure with or without excessive bradycardia, leading to a r...

SEROTONIN SYNDROME CAUSED BY MOCLOBEMIDE – CLOMIPRAMIN INTERACTION The serotonin syndrome is due to serotoninergic hyperstimulation, which is caused, mostly, by the interaction between a serotoninergic agent and a serotonin-enhancing drug, in particular the monoaminooxidase inhibitors. A male patient, 21 years old, with presenting symptoms and findings as unconsciousness, flushing, diaphoresis,...

OBJECTIVE To evaluate use of clomipramine, alprazolam, and behavior modification for treatment of storm phobia in dogs. DESIGN Prospective open clinical trial. ANIMALS 40 dogs with storm phobia. PROCEDURE Dogs received clomipramine at a dosage of 2 mg/kg (0.9 mg/lb), PO, every 12 hours for 3 months; then 1 mg/kg (0.45 mg/lb), PO, every 12 hours for 2 weeks; then 0.5 mg/kg (0.23 mg/lb), PO...

Background.A review of the efficacy of antidepressantdrug treatment in patients with obsessive—compulsive disorder(OCD), usinga meta-analyticapproach. Method. Randomiseddouble-blindclinicaltrialsof antidepressantdrugs,carriedout among patients with OCD and publishedin peer-reviewedjournalsbetween 1975 and May 1994, were selectedtogetherwith three studiescurrentlyin press.Forty-seventrialswere...

There have been many attempts to find predictors of the therapeutic response to the clomipramine treatment of obsessive-compulsive disorder. The majority of studies have failed to identify such predictors. Possible reasons for this failure include the small sample size of most studies, samples homogeneous with respect to the study factors of interest, and the use of statistical procedures that ...

Clomipramine hydrochloride, active component of an antidepressant drug, was determined in the pharmaceutical formulation by two kinds of potentiometric sensor; a PVC membrane sensor and a carbon paste electrode modified by MWCNTs and ionic liquid. Both sensors were corporated with clomipramine-tetraphenylborate ion-pair complex and they respond based on ion exchange mechanism. The best PVC memb...