PURPOSE To investigate the interobserver variations in delineation of lumpectomy cavity (LC) and clinical target volume (CTV), and its impact on irradiated volume in accelerated partial breast irradiation using intraoperative multicatheter brachytherapy. MATERIAL AND METHODS Delineation of LC and CTV was done by five radiation oncologists on planning computed tomography (CT) scans of 20 patie...

PURPOSE To determine the variation in target delineation of nasopharyngeal carcinoma and the impact of measures to minimize this variation. MATERIALS AND METHODS For ten nasopharyngeal cancer patients, ten observers each delineated the Clinical Target Volume (CTV) and the CTV elective. After 3D analysis of the delineated volumes, a second delineation was performed. This implied improved delin...

To clarify the length and volume reduction of seminal vesicles (SVs) after neo-adjuvant hormonal therapy (NHT), in order to help contour optimal SV included into high-dose clinical target (CTV) for radiotherapy intermediate- high-risk patients. MR images both before NHT (5.3 ​± ​2.2 months) were collected from thirty-one patients with cT2-4N0M0 prostate cancer. was measured axial T1WI, while ob...

BACKGROUND Recurrence rates following radiotherapy for prostate cancer in the post-operative adjuvant or salvage setting remain substantial. Previous work from our institution demonstrated that published prostate bed CTV guidelines frequently do not cover the pre-operative MRI defined prostate. Inadequate target delineation may contribute to the high recurrence rates, but increasing target volu...

A 67-year old man with a history of papillary thyroid cancer (PTC) presented with metastatic disease to the left colon in the form of a 6.1x1.0 cm bleeding, ulcerated mass. Radiopaque surgical clips were used as fiducial markers to localize the gross tumor volume (GTV) as well as the corresponding clinical target volume (CTV) and planning target volume (PTV). Daily cone beam computed tomography...

The name “Brachytherapy” is derived from ancient Greek words for short distance (brachios) and treatment (therapy) and refers to the therapeutic use of encapsulated radionuclides placed within or close to the tumor. Brachytherapy (BT), used as an integral part of cancer treatment for almost a century, developed in last three decades a rapid growth with the development of afterloading devices an...

OBJECTIVE We hypothesized that omission of clinical target volumes (CTV) in lung cancer radiotherapy would not compromise control by determining retrospectively if the addition of a CTV would encompass the site of failure. METHODS Stage II-III patients were treated from 2009-2012 with daily cone-beam imaging and a 5 mm planning target volume (PTV) without a CTV. PTVs were expanded 1 cm and te...

PURPOSE The present project studied the implications of using the irregular surface compensator (ISC) technique in comparison to three-dimensional conformal radiation therapy (3D-CRT) for breast cancer treatment. ISC is an electronic compensation algorithm that modulates the fluence across the radiation fields to compensate for irregularly-shaped surfaces and deliver a homogeneous dose to a com...

To investigate the plan quality of tri-Co-60 intensity-modulated radiation therapy (IMRT) with magnetic-resonance image-guided radiation therapy compared with volumetric-modulated arc therapy (VMAT) for prostate cancer. Twenty patients with intermediate-risk prostate cancer, who received radical VMAT were selected. Additional tri-Co-60 IMRT plans were generated for each patient. Both primary an...

PURPOSE The goals of this study were to measure inter- and intrafraction setup error and prostate bed motion (PBM) in patients undergoing post-prostatectomy image-guided radiotherapy (IGRT) and to propose appropriate population-based three-dimensional clinical target volume to planning target volume (CTV-PTV) margins in both non-IGRT and IGRT scenarios. METHODS AND MATERIALS In this prospecti...