meropenem, a carbapenem antibiotic, has a broad-spectrum activity and is active against staphylococcus aureus, streptococcus pneumoniae, haemophilus influencae, moraxella catarrhalis, gram-negative enteric bacilli as escherichia coli, klebsiella, enterobacter, serratia and pseudomonas aeruginosa. meropenem has excellent penetration in body tissues and in cerebrospinal fluid (in the presence of ...

FocalinTM XR (dexmethylphenidate hydrochloride) extended-release capsules is an extended-release formulation of dexmethylphenidate with a bi-modal release profile. FocalinXR uses the proprietary SODASTM (Spheroidal Oral Drug Absorption System) technology. Each bead-filled Focalin XR capsule contains half the dose as immediate-release beads and half as enteric-coated, delayed-release beads, thus...

ONE OF THE more significant advances in cardiovascular therapeutics in the past decade has been the introduction of 3-adrenergic blocking drugs. This review is prompted by the expanding indications and more widespread use of this group of drugs. Although several compounds have been developed, propranolol was the first to gain wide acceptance and remains the only one available for general use in...

Studies on pivampicillin hydrochloride and ampicillin trihydrate, administered in capsules to healthy volunteers, indicated that pivampicillin was absorbed more efficiently from the gastrointestinal tract than ampicillin. Average peak concentrations of ampicillin in the serum after doses equimolar to 250 mg of ampicillin were 6.8 mug/ml at 56 min with pivampicillin and 1.96 mug/ml at 1 h 24 min...

FoR this new edition of Dilling's Clinical Pharmacology extensive revision has been undertaken by the staff of the Department of Materia Medica and Therapeutics of Glasgow University, based in the Stobhill and the Western District Hospitals. For medical students it is good that so many of the modern textbooks of pharmacology are written by authors familiar not only with pharmacology but also wi...

The advances in developmental pharmacokinetics during the past decade reside with an enhanced understanding of the influence of growth and development on drug absorption, distribution, metabolism, and excretion (ADME). However, significant information gaps remain with respect to our ability to characterize the impact of ontogeny on the activity of important drug metabolizing enzymes, transporte...

Monitoring of fundamental physiological variables during anaesthesia is considered essential, but as we develop the ability to monitor more functions, information overload may become a problem. A distributed situation awareness framework is what we need to perceive elements in the environment (detection), comprehend the current situation (diagnosis), and make projections of future status (predi...

Objectives: Atherosclerosis is a disease process involving the early deposition of lipids in the vessel wall trapped by modified proteoglycans and subsequently a chronic inflammatory process leading to the clinical events. MTX has been chosen to study the potential efficacy of an anti inflammatory agent in preventing atherosclerosis and secondary cardiovascular disease in the cardiovascular inf...