AIM To investigate serum creatinine and electrolyte status of children with diarrhea-related hyponatremic or hypernatremic dehydration. METHODS Medical history of 83 patients admitted to the Pediatric Intensive Care Unit of the Konya Education and Research Hospital, Konya, Turkey with diarrhea, dehydration and electrolyte imbalance was retrospectively evaluated according to the degree of dehy...

Background:Naltrexone is a competitive opioid receptor antagonist blocking the euphoric effects of exogenous opioids. When used concomitantly with opioids, naltrexone causes severe withdrawal symptoms.The main aim of the study is to determine the symptomatology and outcome of patients who consumed naltrexone in conjunction with an opioid substance. Methods:This cross-sectional study was perf...

background:  pericardial effusion (pe) in down syndrome (ds) patients  usually occur s   secondary to hypothyroidism,  but  we have   no  report of massive pericardial effusion in   euthyroid   down syndrome patient with  supravalvar  pulmonary stenosis . case presentation:  we  report ed   an   11-month-old  male with down syndrome   with  massive  pericardial  effusion that  had conservative ...

Since the discovery of circulating microRNAs (miRNAs) in body fluids, an increasing number of studies have focused on their potential as non-invasive biomarkers and as therapeutic targets or tools for many diseases, particularly for cancers. Because of their stability, miRNAs are easily detectable in body fluids. Extracellular miRNAs have potential as biomarkers for the prediction and prognosis...

Endometriosis is a common mysterious and fascinating gynaecological condition with diverse clinical manifestations, highly variable and unpredictable clinical course with decreased quality of life. Clinically, Salvia miltiorrhiza Bunge (SMB, Chinese Danshen) has been applied to treat endometriosis and get satisfactory results. The present study was aimed to explore the effects of the extracts o...

Natural flavonoids, alkaloids, saponins and sesquiterpenoids have been extensively investigated because of their biological and physiological significances, as well as their promising clinical uses. It is necessary to monitor them or their metabolites in biological fluids for both pre-clinical studies and routine clinical uses. The successful hyphenation of LC and MS, which was thought as "the ...

Novel low-glucose degradation products (GDP) peritoneal dialysis (PD) fluids have an improved biocompatibility profile as compared to standard fluids. Clinical studies suggest that their use may be associated with favorable clinical outcomes; however, large prospective randomized studies addressing clinical endpoints such as patient and technique survival are presently lacking. Nevertheless, as...

There is growing interest in the use of alternate biological fluids for drug testing. An advantage of oral fluids is that collection can be made from individuals under direct observation without undue embarrassment or invasion of privacy. This study evaluated the STC Cocaine Metabolite MICRO-PLATE EIA for use in detection of cocaine and metabolites in oral fluids. Intra- and interassay precisio...

Extracellular vesicles (EVs) provide real-time information about the physiological and pathological states of parental cells are potential biomarkers for disease diagnosis. Many methods isolating EVs from body fluids techniques analyzing biomolecules, including protein, nucleic acids, lipids, have emerged with clinical application.

Extracellular vesicles (EVs) are secreted by cells into the extracellular space, first discovered in 1967 as platelet dust. In recent years, idea that EVs can treat various diseases has emerged studies to understand these vesicles' origin and biological functions. According their size, biogenesis, content, release pathways function, have three main subtypes: microvesicle (MV), exosome (EX) apop...