Embryonic stem cell-derived cardiomyocytes (ESC-CMs) hold great interest in many fields of research including clinical applications such as stem cell and gene therapy for cardiac repair or regeneration. ESC-CMs are also used as a platform tool for pharmacological tests or for investigations of cardiac remodeling. ESC-CMs have many different aspects of morphology, electrophysiology, calcium hand...

Dorland’s Illustrated Medical Dictionary in its 24th Edition (1965), describes the term “Electrophysiology” as “The Science of physiology in its relations to electricity; the study of the electric reactions of the body in health.” The ability of scientists to observe and record physiology’s electrical phenomena long preceded the understanding of the membranous ionic processes that are responsib...

Mathematical modeling of cardiac function can provide augmented simulation-based diagnosis tool for complementing and extending human understanding diseases which represent the most common cause worldwide death. As realistic starting-point developing an unified meshless approach total heart modeling, herein we propose integrative smoothed particle hydrodynamics (SPH) framework addressing simula...