Proline rich 11 (PRR11) serves an important role in the development and progression of a number of types of human cancer. However, the clinical role of PRR11 in tongue squamous cell carcinoma (TSCC) remains unknown. The present study aimed to investigate the expression and clini‐ copathological significance of PRR11 in TSCC. The Cancer Genome Atlas analysis demonstrated that the upregulation of...

Clinical Use of Digitalis Glycosides The potential benefit of digoxin therapy in heart failure patients is thought to be related to its positive inotropic effect that increases cardiac output and thereby decreases ventricular filling pressures.2 Although digoxin is undoubtedly an inotropic agent in tissue preparations,3 this effect, in contrast to other inotropic agents, is not consistently tra...

C RPS is a pa infu l con d ition which usually dev elops after trauma to a limb . It is chnracrerbed by l imb_confln~-d sensory, autonomic, moto r, skin and bon e cha nges, btu the lead symptom is pain. Earlier names for the condi tion are given in appendix A. 111e C Rrs diagno stic crite ria have recently been up dated ('Budape sr Criteria", appendi x B}, because earlier criteria were nor spec...

Papillary microcarcinoma of the thyroid (mPTC) is defined by the WHO as a papillary thy-roid cancer measuring 10mm or less in diameter and it is nowadays a topic of intense debate among the members of the medical community due to its apparent "epidemic" rise. Although these tumors follow almost always an indolent clinical course and carry an excellent prognosis, it is known that a small sub-set...

Abstraet-Neurophysiological studies in cats have established a functional relationship between waking 12-15 Hz sensorimotor cortex rhythmic EEG activity (the sensorimotor rhythm or SMR) and a similar pattern during sleep, the sleep spindle. Both result from oscillatory thalamocortical discharge involving ventrobasal thalamus and sensorimotor cortex, and both are associated with a state of suppr...

The purine nucleoside analogs, toyocamycin, tubercidin, and 6-thioguanosine, all inhibit ribosomal RNA maturation in cultured Novikoff hepatoma cells. While processing of the 45 S RNA to the 38 S RNA continues, formation of the mature 28 S RNA and the mature 18 S RNA is markedly inhibited by the addition of any of the analogs. Labeling of the 32 S RNA intermediate precursor is inhibited to a le...

Maugeri Foundation Respiratory Failure item set (MRF-28) questionnaire [3] assessment in the treated subjects, also showed a positive impact of one of the most important endpoints of the long-term ventilatory strategy in these patients, which is the health-related quality of life (HRQoL). Although, it is still not clear whether survival can be positively influenced by NPPV in addition to standa...

National Cancer Institute, USPHS. Presented in part at the 62nd Annual Meeting of the American Association for Cancer Research, Inc., Chicago. 111..April 1971 (37). 2Career Development Awardee of the National Cancer Institute (IK4-CA-8245-05). 3The abbreviations used are: HMM, hexamethylmelamine [2,4,6tris(dimethylamino)-i-lriazine] (NSC-13875); TEM, triethylenemelamine [2,4,6-tris(l-aziridinyl...

Up until recently, the prevailing dogma was that insulin secretion ceased within a couple of years after the diagnosis of type I diabetes, a clinical time period called the honeymoon. But a series of recent studies have established that release of C-peptide, which is the best measure of endogenous insulin production, can commonly persist for decades after disease onset. The release of C-peptide...

BACKGROUND & OBJECTIVES Visceral leishmaniasis (VL) is a fatal zoonotic disease in tropical and sub-tropical countries including Iran. Dogs constitute the main domestic reservoir for VL (kala-azar) in Iran but incidence of the disease in cats from Fars and East Azerbaijan provinces has led to propose them as secondary reservoirs, and possible expansion of the feline role in the transmission of ...