MHC class II tetramers have emerged as an important tool for characterization of the specificity and phenotype of CD4 T cell immune responses, useful in a large variety of disease and vaccine studies. Issues of specific T cell frequency, biodistribution, and avidity, coupled with the large genetic diversity of potential class II restriction elements, require targeted experimental design. Transl...

Losses in follow-up that are biased with respect to outcome invalidate the results. There are many ways of dealing with non-response in follow-up studies. Three separate methods were used to investigate a potential bias in a mail survey of 2471 disabled people. At a response rate of 84%, the non-respondents were significantly different from the respondents with respect to the outcome, return to...