Deoxycytidine kinase (dCK) is one of the key enzymes of deoxynucleoside salvage supplying resting lymphocytes with DNA precursors for synthesis and repair. The level of dCK activity is especially important in chemotherapy with the use of deoxynucleoside analogues like arabinosyl cytosine (Citarabid, ara-C), or 2-chloro-deoxyadenosine (Cladribine, CdA). Previous results showed that Cladribine tr...

INTRODUCTION Pentostatin (2'-deoxycoformycin) and cladribine (2-chlorodeoxyadenosine) are adenosine analogues widely used to treat lymphoid malignancies, mainly hairy cell leukemia (HCL). Oral or parenteral adenosine analogues have been also used as immunomodulatory agents in multiple sclerosis and in acute graft-versus-host disease. CASE REPORT Here, we report the case of a 43-year-old patie...

Background Disease modifying treatments (DMTs) have transformed the management of people with MS (pwMS). However, patients an EDSS>6.5 (pwAMS) are considered beyond DMT due to (i) focus on ambulation as outcome measure, (ii) assumption that in pwAMS inflammation plays no role, and (iii) disregard for potentially length-dependent neuro-axonal damage. Cladribine is a CNS penetrant, effective, ...

introduction: hcl is a rare malignant condition that is curable if diagnosed early. hcl can present with reduced blood cells and splenomegaly which maybe misdiagnosed with other conditions. the aim of the present study was to determine the frequency of early clinical and laboratory findings as well as the response rate of patients to the standard treatment regimen of cladribine. methods: the st...

Novakovic, A. M. 2017. Longitudinal Models for Quantifying Disease and Therapeutic Response in Multiple Sclerosis. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Pharmacy 225. 71 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-554-9836-8. Treatment of patients with multiple sclerosis (MS) and development of new therapies have been challenging due to the di...