نتایج جستجو برای: citalopram hydrobromide

تعداد نتایج: 3768  

Journal: :Pharmacological reports : PR 2011
Bhagawati Saxena Sanjay Singh

The present study investigates the gastroprotective effect of citalopram, an antidepressant drug. Gastroprotective activity of citalopram (5, 10 and 20 mg/kg, bid, po) was evaluated both by single and 14 days repeated pretreatment in the cold restraint stress (CRS) model and 14 days repeated pretreatment in pyloric ligation (PL) model. In addition to ulcer scoring and its histological assessmen...

Journal: :Cardiology journal 2014
Yihong Zhang Adrian Baranchuk Jules C Hancox

Citalopram is a serotonin-selective reuptake inhibitor (SSRI) widely used in the treatment of major depression and sometimes also anxiety-associated conditions, obsessive compulsive disorder and behavior disturbances associated with dementia [1, 2]. Citalopram is relatively well tolerated and has been considered to have comparatively low potential for drug–drug interactions and anti-adrenergic ...

Journal: :European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2013
Louise Karlsson Björn Carlsson Christoph Hiemke Johan Ahlner Finn Bengtsson Ulrich Schmitt Fredrik C Kugelberg

According to both in vitro and in vivo data P-glycoprotein (P-gp) may restrict the uptake of several antidepressants into the brain, thus contributing to the poor success rate of current antidepressant therapies. The therapeutic activity of citalopram resides in the S-enantiomer, whereas the R-enantiomer is practically devoid of serotonin reuptake potency. To date, no in vivo data are available...

Journal: :ACS chemical neuroscience 2011
Steven Combs Kristian Kaufmann Julie R Field Randy D Blakely Jens Meiler

The human serotonin (5-hydroxytryptamine, 5-HT) transporter (hSERT) is responsible for the reuptake of 5-HT following synaptic release, as well as for import of the biogenic amine into several non-5-HT synthesizing cells including platelets. The antidepressant citalopram blocks SERT and thereby inhibits the transport of 5-HT. To identify key residues establishing high-affinity citalopram bindin...

Journal: :Indian journal of experimental biology 2010
Anil Kumar Ruchika Garg Vaibhav Gaur Puneet Kumar

Stress is an aversive stimulus which disturbs physiological homeostasis and is reflected on a variety of biological systems. The present study was designed to investigate the nitric oxide mechanism in neuroprotective effect of trazodone and citalopram against acute immobilization-induced behavioral and biochemical alteration in mice. Mice were immobilized for a 6 h. Acute immobilization stress ...

2012
Zuhal UCKUN H. Sinan SÜZEN

Citalopram has by far the highest selectivity for serotonin reuptake and is used for the treatment of depression. Therapeutic drug monitoring is clinically important for psychiatrists in terms of therapy success. In this work a simplified, rapid, sensitive, selective and validated high performance liquid chromatographic method for the determination of racemic citalopram and its main metabolite ...

2005
Nasser Naghdi Nahid Majlessi

Data on the effects of serotonin reuptake inhibitors on learning and memory processes are not consistent. In the present study, the effects of citalopram, a very potent and completely selective inhibitor of the serotonin reuptake on spatial discrimination in the T-maze and Morris water maze, were assessed in mice and/or rats. Animals received different doses of citalopram (1, 2, 4, 8 or 16 mg/k...

نقدی, ناصر, رشیدی پور, علی, صریحی , عبدالرحمن , معتمدی , فرشته ,

The role of serotonergic systems in learning processes is even more controversial: For example serotonergic lesion have been reported to facilitate, impair, or have no effect on performance in various learning tasks. There are several possible explanations for these discrepancies; different importance of  confounding activation of different learning processes, different importance of con...

2015
Woo Fong Yen Mahiran Basri Mansor Ahmad Maznah Ismail

Galantamine hydrobromide is formulated in tablets and capsules prescribed through oral delivery for the treatment of Alzheimer's disease. However, oral delivery of drugs can cause severe side effects such as nausea, vomiting, and gastrointestinal disturbance. Transdermal delivery of galantamine hydrobromide could avoid these unwanted side effects. In this work, galantamine hydrobromide was form...

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