The reaction of cis-[Pt(NO(3))(2)(NH(3))(2)] and sodium glycolate yielded the title compound, [Pt(C(2)H(2)O(3))(NH(3))(2)]. The Pt(II) atom, coordinated by two N atoms of ammine and two O atoms of the carboxyl-ate and oxido groups of the glycolate ligand, is in a square-planar environment. In the crystal structure, mol-ecules are connected by inter-molecular N-H⋯O hydrogen bonds, forming a thre...

The title compound, [PtCl(2)(C(31)H(32)NP)], is a Pt(II) complex with an NPCl(2) coordination sphere in which the Pt(II) atom is coordinated to the imino N and phosphane P atoms of the ligand and to two cis Cl ions, giving a slightly distorted square-planar geometry. The P-Pt-N angle is 89.80 (5)° and the corresponding angle between the Cl ions is 87.92 (2)°.

Two tautomers of the new phosphinoaminothiazoline Ph2PNHC=NCH2CH2S, obtained from the reaction of 2-amino-2-thiazoline (ATHZ) with Ph(2)PCl, have been structurally characterized and the intermediate formation of the diphosphine Ph2PN=CN(PPh2)CH2CH2S has been demonstrated experimentally and by DFT calculations; reacts with [AuCl(THT)] to give [(AuCl)2] whereas the bidentate metalloligand cis-[Pt...

The title complex, [PtCl(2)(C(18)H(40)P(2))], contains a Pt(II) center in an approximately square-planar geometry [cis angle range = 88.09 (3)-91.39 (3)°; twist angle = 1.19 (5)°]. The Pt-P bond lengths of 2.2536 (8) and 2.2513 (8) Å and the Pt-Cl bond lengths of 2.3750 (8) and 2.3588 (8) Å are normal. This crystal form is a polymorph of a structure reported previously [Harada, Kai, Yasuoka & K...

The title compound, [PtCl(2)(C(20)H(20)P)(2)]·C(4)H(8)O(2), crystallizes with the Pt atom in a distorted cis-square-planar geometry. The Pt-P bond lengths are 2.2490 (19) and 2.253 (2) Å, and the Pt-Cl bond lengths are 2.344 (2) and 2.3475 (18) Å. Some weak C-H⋯Cl and C-H⋯O inter-actions involving the solvate mol-ecule were observed.

Construction of a library of structurally diverse diazenecarboxamide-extended cis-[Pt(2-picolyl-1,2,3-triazole)Cl2,] and cis-[Pt(propan-1,3-diamine)CBDCA] (CBDCA = 1,1 -cyclobutanedicarboxylate) complexes 1-4 is described. These compounds retain oxidative properties of parent diazenecarboxamides against glutathione as demonstrated by NMR spectroscopy and high resolution mass spectrometry experi...

The Pt complex [meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)-ethylenediamine]diaqua -Pt(II) sulfate (meso-6-PtSO4) was designed with the concept of combining the cytotoxic cisplatin with an estrogen receptor (ER)-binding ligand for targeting to ER+ mammary tumor cells. This Pt complex selectively inhibits growth of ER+ mammary tumors in rodents. To study the cellular mechanisms of action, culture...

Small decreases in serum Ca(2+) and more prolonged increases in serum phosphate (P(i)) stimulate the parathyroid (PT) to secrete parathyroid hormone (PTH), and 1,25(OH)(2)D(3) decreases PTH synthesis and secretion. A prolonged decrease in serum Ca(2+) and 1,25(OH)(2)D(3), or increase in serum P(i), such as in patients with chronic renal failure, leads to the appropriate secondary increase in se...

We present the method of theoretical calculations of the Raman intensities and the simulated Raman spectra of platinum(II) complexes. Theoretical Raman spectra of the anticancer agents: cisplatin (1), carboplatin (2), cis-[Pt(orotato)(NH3)2] (3), cis[PtCl2(NH3)(2-picoline)], ZD0473 (4), and the two transient species of 4 (the hydrolysis products) were calculated by density functional mPW1PW met...

The objective of this study is determination the volatile compounds of Matricaria chamomilla of an inorganic–organic hybrid material based on ZnO nanoparticles anchored to a composite made from polythiophene and hexagonally ordered silica (ZnO/PT/SBA-15) as a solid-phase fiber microextraction (SPME). Microextraction techniques with nanoparticles ZnO/PT/SBA-15 resulted in a more efficient analyt...