1'-Diphenylphosphino-1-{[(2-(methylthio)ethyl)amino]carbonyl}ferrocene (1), accessible via amidation of 1'-(diphenylphosphino)ferrocene-1-carboxylic acid (Hdpf) with 2-(methylthio)ethylamine, reacts with [PdCl2(cod)] (cod = cycloocta-1,5-diene) at a 1 : 1 metal-to-ligand ratio to give trans-[PdCl2(1-κ(2)P,S)] (trans-2) as the sole product. A similar reaction with [PtCl2(cod)] affords a mixture ...

Background: Naturally extracted trans-(−)-kusunokinin from P. nigrum showed anticancer activities via binding and inhibition of CSF1R. However, the synthetic racemic mixtures trans-(−)- trans-(+)-kusunokinin (trans-(±)-kusunokinin) exhibited different effects on breast cancer cell lines. It was hypothesized that trans-(±)-kusunokinin bind to additional molecules, including AKR1B1. Previously, w...

Amyloid-β (Aβ) self-assembly into cross-β amyloidfibrils is implicated in a causative role in Alzheimer’s disease pathology.Uncertainties persist regarding the mechanisms of amyloid self assembly and the role of metastable prefibrillar aggregates. Aβ fibrilsfeature a sheet-turn-sheet motif in the constituent β-strands; as such, turn nucleation has been proposed as a rate-limiting step in the se...

tagetes is a genus of 56 species of annual and perennial mostly herbaceous plants in the sunflower family (asteraceae or compositae).in this research our goal was recognizing the main components of the plant to extract useful ones. essential oils of the leaves, seeds and flowers of tagets minuta l., growing wild in iran, were extracted by hydrodistillation and analyzed by gc and gc-ms. identifi...

Digesta samples from the ovine rumen and pure ruminal bacteria were incubated with linoleic acid (LA) in deuterium oxide-containing buffer to investigate the mechanisms of the formation of conjugated linoleic acids (CLAs). Rumenic acid (RA; cis-9,trans-11-18:2), trans-9,trans-11-18:2, and trans-10,cis-12-18:2 were the major CLA intermediates formed from LA in ruminal digesta, with traces of tra...