This case discusses the management of an 83-year-old female patient from Lebanon with Sjogren's Syndrome and Cicatricial Bullous Pemphigoid. The presented in January 2021 to internal medicine clinic for evaluation on off pruritic, burning blisters lower abdomen pubic area. She has hypothyroidism a 40 year long history difficulty exhaling through her nose. Family social unremarkable except using...

AIM To study the MUC5AC and the blood group related antigen expression in ocular cicatricial pemphigoid (OCP) according to the distribution of Lewis and secretor phenotypes in OCP patients compared to normal subjects. METHODS Immunostaining was performed on conjunctival biopsy specimens from 22 consecutive patients suffering from OCP, using monoclonal antibodies (Mabs) directed against the pe...

RESULTS. Compared with the control, increased accumulations of type I and type III collagens were detected by immunohistochemistry in fibrotic conjunctiva of patients with OCP. Weak and sparse expression of HSP47 was detected in the epithelial cells and stromal fibroblasts in control conjunctival tissues. In contrast to the control, the expression of HSP47 was markedly increased in the stromal ...

UNLABELLED Direct immunofluorescence (DIF) is widely used for the diagnosis of bullous diseases and other autoimmune pathologies such as oral lichen planus. There is no evidence in the literature on how the following variants influence the detection rate of DIF: intraoral site chosen for the biopsy, perilesional locus or distant site from the clinical lesion, number of biopsies and instrument u...

Sir, Cicatricial pemphigoid (CP) is a rare autoimmune subepithelial blistering disease that predominantly affects the mucous membranes with scarring (1). The disease is characterized by the involvement of muco-cutaneous sites, among them ocular invo-lvement, which can lead to blindness. Mild forms of the disease may be controlled by anti-inflammatory drugs, such as dapsone, whereas severe forms...

UNLABELLED The cicatricial alopecias encompass a diverse group of disorders characterized by permanent destruction of the hair follicle and irreversible hair loss. Destruction of the hair follicle can result from primary, folliculocentric disease or as a secondary result. This article focuses on the former, or primary cicatricial alopecias. The cause and pathogenesis of many of these disorders ...