OBJECTIVES To determine the effect of the off-pump technique in preventing stroke development during the early perioperative period after coronary artery bypass graft surgery (CABG). METHODS Patients undergoing isolated CABG surgery were enrolled from 21 Spanish cardiac-surgery centres. Baseline variables related to perioperative stroke risk were recorded in the preoperative (age, gender, dia...

There is increasing recognition of the involvement of the immune signaling molecule, tumor necrosis factor (TNF), in the pathophysiology of stroke and chronic brain dysfunction. TNF plays an important role both in modulating synaptic function and in the pathogenesis of neuropathic pain. Etanercept is a recombinant therapeutic that neutralizes pathologic levels of TNF. Brain imaging has demonstr...

This study provides a parallel characterization of the cytokine and chemokine response to stroke in the human and mouse brain at different stages of infarct resolution. The study goal was to address the hypothesis that chronic inflammation may contribute to stroke-related dementia. We used C57BL/6 and BALB/c mice to control for strain related differences in the mouse immune response. Our data i...

OBJECTIVE To clarify how participation in leisure activities and exercise by chronic stroke survivors differs before and after a stroke. METHODS Sixty chronic stroke survivors receiving community-based rehabilitation services from a health center in Seongnam City were recruited. They completed a questionnaire survey regarding their demographic characteristics and accompanying diseases, and on...

Structural changes after ischemic stroke could affect information communication extensively in the brain network. It is likely that the defects in the white matter (WM) network play a key role in information interchange. In this study, we used graph theoretical analysis to examine potential organization alteration in the WM network architecture derived from diffusion tensor images from subjects...

atherosclerosis is the most common cause of myocardial infarction and ischemic stroke. various risk factors have been identified for atherosclerosis. recently, bacterial and viral organisms, which are involved in chronic inflammatory processes, have been also implicated in atherosclerosis development. individuals with a prior history of periodontal diseases and/or tooth loss are considered to be...

objectives: spasticity and contracture in flexor muscles of the wrist may occur after stroke, especially in which early recovery did not appear. splints are prescribed to reduce spasticity and to prevent contracture after stroke. although there is a few research in this field. the aim of this study was to examine the impact of the extension splint on function, spasticity, and range of motion of...