omalizumab is a recombinant humanized anti-ig e monoclonal antibody used as the third line treatment of chronic spontaneous urticaria (csu). we report four patients with severe antihistamine-resistant csu, who developed angioedema, anaphylaxis and/or flare up of urticaria at different times following omalizumab therapy.

background: more than 350 million people are chronic carriers of hepatitis b virus (hbv) and because of the high hbv-related morbidity and mortality, the global disease burden of hbv is substantial. in patients with hbeag–negative chronic hepatitis b (chb) with serum alanine aminotransferase (alt) levels, 1-2 × upper limit of normal (uln) and hbv dna load of 10000 to 100000 copies/ml, liver bio...

chronic pain is a prevalent and debilitating condition, conveying immense human burden. suffering from chronic pain is not only caused by painful symptomatology, but also through a wide range of psychopathological and physical consequences, including depression and anxiety disorders, impaired sleep and cognition, cardiovascular morbidity and impaired sexual function, all contributing to diminis...

idiopathic inflammatory myopathies are a heterogeneous group of muscle disorders characterized by chronic muscle inflammation and progressive muscle weakness. polymyositis (pm), dermatomyositis (dm) and inclusion body myositis (ibm) are the three major subsets based on distinct clinical and histopathological features. since the pathogenesis remains unclear, therapeutic approaches actually compr...

objective: trichomonas species usually reside in the mouth and occasionally in the respiratory tract. these species can be found in the lungs of humans. although the pathogenicity of the parasite in the respiratory system has not been proven, it is more prevalent in people who lack good oral health or suffer from asthma or chronic pulmonary diseases. in the present descriptive study, we have id...

conclusions the number of subjects with cp proved it as a prevalent problem in the study population. furthermore, characteristics and associations of those experiencing cp demonstrated that it might have significant negative health and psychosocial outcomes in this group. the problem was found significant enough to consider special health programs to prevent and manage cp in urban population of...

conclusions cognitive behavior therapy was more effective than the other psychotherapy approaches relieving chronic pain in the studies. well-designed studies and comprehensive clarification of the studies demonstrating groups, intervention, follow-up and drop outs can improve the quality of the rcts. context keeping in mind the burden of psychotherapy can play a crucial role concerning chronic...

background: erectile dysfunction (ed) is recognized as a major health problem .chronic diseases such as chronic hepatitis, and its treatment can have negative effect on erectile function. the aim of this study was assessment the correlations of erectile dysfunction with depression in patients with chronic hepatitis methods: in this descriptive and analytical study, 70 male patients with chronic...

introduction: stress is defined as any environmental change that disturbs the maintenance of brain homeostasis. stress leads to production of pro-inflammatory cytokines that provoke neurodegenerative disorders. in the present study, we investigated the effects of dalteparin on hippocampal neuronal death induced by chronic stress in rats. methods: the study was carried out on 60 adult male wista...

abstract objective immune thrombocytopenic purpura (itp) manifests as an easy bruising or extravasation of blood from capillaries into skin and mucous membranes. the characteristics of acute itp in infants have rarely been described. in order to better understand acute itp in infants, the characteristics of the disease at this age group was investigated. material and methods the present descrip...