Normal wound healing is accomplished through a series of well-coordinated, progressive events with overlapping phases. Chronic wounds are described as not progressing to healing or not being responsive to management in a timely manner. A consensus panel of multidisciplinary wound care professionals was assembled to (1) educate wound care practitioners by identifying key principles of the basic ...

Traumatic and non-traumatic injuries are common complications in the aging adult. Inflammation is related to aging in older individuals and may lead to an increased risk of mortality, reduced muscle strength, and decreased mobility. Unresolved inflammation could be related to the origin of many chronic diseases associated with aging such as autoimmune and neurodegenerative diseases or tumors. W...

Chronic non-healing wounds show delayed and incomplete healing processes and in turn expose patients to a high risk of infection. Treatment currently focuses on dressings that prevent microbial infiltration and keep a balanced moisture and gas exchange environment. Antibacterial delivery from dressings has existed for some time, with responsive systems now aiming to trigger release only if infe...

Aberrant wound healing can lead to a variety of human pathologies, from non-healing chronic wounds that can become dangerously infected, to exuberant fibrotic healing in which repair is accompanied by excessive inflammation. To guide therapeutic intervention, we need a better understanding of the fundamental mechanisms driving tissue repair; this will require complementary wound-healing studies...

Wound healing is a dynamic and complex biological process involving highly organised overlapping phases, including coagulation, inflammation, epithelialisation, matrix deposition, angiogenesis, proliferation, cellular remodelling and wound contraction (Clark, 1985; Mast and Schultz, 1996). For completion of each stage of wound healing, complex interactions must occur between various biological ...

Chronic wounds represent a significant health problem, especially in diabetic patients. In the current study, we investigated a novel therapeutic approach to wound healing--whole body low-intensity vibration (LIV). LIV is anabolic for bone, by stimulating the release of growth factors, and modulating stem cell proliferation and differentiation. We hypothesized that LIV improves the delayed woun...

R Gary Sibbald is Professor, Medicine and Public Health Science; Director of Continuing Education, Department of Medicine, University of Toronto; Director of Dermatology, Daycare and Wound Healing Clinic, Sunnybrook and Women’s Health Sciences Centre; Toronto Wound Healing Centres, Toronto, Ontario; and Chairman (Toronto Meeting 2008) of the World Union of Wound Healing Societies. Adam Katchky ...

Wound healing is a complex process that proceeds through a number of welldefined and orchestrated stages: inflammation, proliferation, matrix deposition, and remodeling (1,2). Enzymatic remodeling of the extracellular matrix (ECM) is considered essential for proper wound healing (3). Various types of proteinases are implicated in ECM degradation, with the major enzymes represented by matrix met...