BACKGROUND Chronic recurrent multifocal osteomyelitis (CRMO) is a little known inflammatory bone disease occurring primarily in children and adolescents. Delays in referral and diagnosis may lead to prolonged courses of antibiotics with in-patient care, unnecessary radiation exposure from multiple plain radiographs or bone scans and repeated surgery including bone biopsies. Children (aged < 18 ...

Background: Chronic recurrent multifocal osteomyelitis (CRMO) is a chronic autoinflammatory disease that primarily affects the skeleton of children and adolescents in absence an infectious etiology[1]. CRMO lesions presentation varies widely ranging from episodic bone pain to growth disturbance; lytic sclerotic can be found on X-ray, however magnetic resonance imaging very useful for evaluating...

Chronic recurrent multifocal osteomyelitis (CRMO) is a non-infectious, inflammatory disorder of the bones. CRMO typically affects children, with predisposition to females. Bone-related pain often felt in metaphysis long bones, particularly lower extremities, but it can also target other sites at varied time intervals. Patients are likely complain tenderness and swelling that may cause considera...

Introduction Chronic recurrent multifocal osteomyelitis (CRMO) is the most severe presentation of the autoinflammatory bone disorder chronic nonbacterial osteomyelitis (CNO). The pathophysiology of CNO remains to be determined. We recently demonstrated reduced activation of mitogen-activated protein kinases ERK1 and 2 in monocytes from CRMO patients responsible for impaired activation of the tr...

PurposeTo investigate the current role of WB-MRI for rheumatic inflammatory diseases in clinical practice using a survey addressed to musculoskeletal radiologists.MethodsA composed 61 questions, subdivided three sections, demographics (five questions), application adults and children (28 questions: 7 open 21 multiple choice each subgroup) was distributed via European Society Musculoskeletal Rad...

OBJECTIVE To determine the clinical outcome of children with chronic recurrent multifocal osteomyelitis (CRMO). METHODS We retrospectively reviewed clinical, biological and radiological data of children with CRMO at five French paediatric centres. Outcome data were obtained through review of hospital charts and questionnaires sent to all patients to assess disease activity and educational and...

INTRODUCTION Chronic recurrent multifocal osteomyelitis (CRMO) is a rare autoinflammatory condition. The clinical picture consists of sterile osteomyelitis, typically with multiple-site lesions in the metaphysis of long bones and not uncommonly, symmetrical bone involvement. It is a poorly understood entity, whose prognosis, etiology and ideal treatment are still controversial. The authors repo...