Fragile X syndrome (FXS) is characterized by synaptic immaturity, cognitive impairment, and behavioral changes. The disorder is caused by transcriptional shutdown in neurons of thefragile X mental retardation 1gene product, fragile X mental retardation protein. Fragile X mental retardation protein is a repressor of dendritic mRNA translation and its silencing leads to dysregulation of synaptica...

BACKGROUND Despite a considerable increase in claims for long-term sickness benefits, and the impact of certifying sickness upon general practitioner (GP) workload, little is known about transition to long-term incapacity for work. AIM To explore the relationship between patient factors and the transition from short-term to long-term work incapacity, in particular focusing on mild mental heal...

OBJECTIVE To assess the feasibility and acceptability of routine web-based screening in general hospital settings, and describe the level of common mental disorder. METHOD A service development platform to integrate mental and physical healthcare was implemented in six specialties (rheumatology, limb reconstruction, hepatitis C, psoriasis, adult congenital heart disease (ACHD), chronic pain) ...

PURPOSE To assess the relationship between the presence of a mental health condition and health care utilization among family medicine patients. METHODS We used the Patient Health Questionnaire plus a posttraumatic stress disorder screen to measure 6 common mental health conditions. In a sample of 367 patients recruited from 3 urban family medicine practices affiliated with Boston University ...

Anxiety disorders, including panic disorder with or without agoraphobia, generalized anxiety disorder, social anxiety disorder, specific phobias, and separation anxiety disorder, are the most prevalent mental disorders and are associated with immense health care costs and a high burden of disease. According to large population-based surveys, up to 33.7% of the population are affected by an anxi...

background: there are critical gaps in assessment and research on health among the elderly living in rural communities. the s tate of aging and health in rural areas provides a snapshot of our older adults’s need to necessary public health measures .the aim of this study was to determine the self-rated general health of adults residing in rural areas and compare the general health of the elderl...

BACKGROUND The household is a potentially important but understudied unit of analysis and intervention in chronic disease research. We sought to estimate the association between living with someone with a chronic condition and one's own chronic condition status. METHODS AND FINDINGS We conducted a cross-sectional analysis of population-based household- and individual-level data collected in 4...

This work is intended as a work of reference for those engaged in research work on mental diseases and so does not lend itself to an abstract. To be appreciated it must be read in the original. The book is beautifully got up. All the illustrations are from original specimens. The reproductions are from untouched photographs. There are four sketches in colour by well-known medical artists and ea...

The authors review contemporary indications for neurosurgical interventions in the management of chronic and refractory mental disorder, the procedures involved, their efficacy and known adverse effects. These data are presented within the context of a brief historical overview of the use of neurosurgery for mental disorder. In addition to a consideration of neurosurgical procedures that rely o...

BACKGROUND Social inequalities in mental disorders have been described, but studies that explain these inequalities are lacking, especially those using diagnostic interviews. This study investigates the contribution of various explanatory factors to the association between educational level and major depression and generalised anxiety disorder in Irish men and women. METHODS The study populat...