BACKGROUND: According to the most recent Egyptian demographic health census, estimated Hepatitis C virus (HCV) prevalence in 15–59 age range was 14.7%. Globally, incidence of renal impairment HCV-positive individuals is 40% higher than HCV-negative patients. HCV-induced can from mild-to-severe, and it frequently complicates treatment outcome HCV infection. AIM: This study aimed explore changes ...

Background and Objective: Infection with the hepatitis C virus (HCV) is an endemic public health problem with long-term consequences, especially in Egypt. Egypt has one of the highest incidence rates of HCV worldwide. The current cross-sectional study aims to determine how prevalent occult HCV infection is and how it affects the individual's immune response. Methods: The studied adult patient...

Background: Treatment of hepatitis C virus (HCV) infection with recently introduced direct-acting antiviral agents (DAA) is effective and safe, however there is little known regarding safety and efficacy of generic DAAs in the real-life clinical setting. This study aimed to evaluate the efficacy and safety of generic sofosbuvir/ledipasvir (SOF/LDV) in a real-life clinical experience. Methods: ...

Objective: To examine whether periodontal disease increases the risk of developing Alzheimer’s and related dementias (ADRD) among hepatitis C patients in Medicare claims data. Background: Periodontal virus (HCV) represent chronic infectious statesthat are common elderly adults. Both conditions have independently been associated with an increased for dementia. Chronic infections thought to lead ...

The present study investigated the association of thyroid dysfunction (TD) with the distribution of chronic hepatitis C virus (HCV) infection in untreated patients. A total of 1,012 cases of HCV-infected patients were collected from different regions, of which 209 patients demonstrated a type of TD (chronic thyroiditis complicated with hyperthyroidism, chronic thyroiditis complicated with hypot...

conclusions the results of this study indicate that the rs12979860 cc genotype of il28b was associated with a response to peg-ifnα-2a/rbv combination therapy in azerbaijani patients with hcv-1b infection. therefore, host genetics may be useful in predicting the response to hepatitis c treatment. objectives the aim of the current study was to determine the relationship between rs12979860 polymor...

INTRODUCTION Hepatitis C virus (HCV) infections remain an increasingly prevalent and emergent health problem worldwide, causing a wide spectrum of liver diseases. Combination therapy with pegylated interferon (PEG-IFN) of peginterferon alfa-2a and oral ribavirin is currently recognized as the standard treatment of chronic HCV infection. Several complex immunological mechanisms are involved duri...

objectives the aim was to study the prevalence of thrombocytopenia in hcv patients without cirrhosis and splenomegaly. patients and methods a cross-sectional study was carried out in the gastrointestinal out patient department (g.i. opd) of the sindh institute of urology and transplantation (siut) from september-november 2013. 30 patients aged between 18 - 60 years with a positive anti-hcv resu...

conclusions examination of the fasting lipid profile has clinical importance in predicting the efficacy of peg-ifn-α-2b plus rbv combination therapy for patients with hcv g1b even after the discovery of the il28 genotype as a potent predictive factor. objectives to re-examine the significance of lipoprotein profiles on virological response to peg-ifn plus rbv combination therapy in patients wit...