نتایج جستجو برای: chronic gvhd

تعداد نتایج: 500551  

Journal: :Haematologica 2005
Norbert Schmitz Meral Beksac Andrea Bacigalupo Tapani Ruutu Arnon Nagler Eliane Gluckman Nigel Russell Jane Apperley Jeff Szerm Kenneth Bradstock Agnes Buzyn Brigitte Schlegelberger James Matcham Alois Gratwohl

BACKGROUND AND OBJECTIVES Allogeneic peripheral blood progenitor cells (PBPC) are now widely used as the source of hematopoietic stem cells for transplantation. However, it is still not clear which patients should receive mobilized PBPC or bone marrow cells to reconstitute hematopoiesis after myeloablative conditioning. The aim of this study is to present 3-year-follow-up data on outcome (incid...

Journal: :Journal of Student Research 2022

This paper attempts to predict the onset of chronic Graft vs. Host Disease (GVHD) in children with blood cancers who have received a bone marrow or stem cell transplant using machine learning models. It analyzes and compares results three different models terms how accurate they each are predicting GVHD. These Logistic Regression, J48 algorithm decision trees, Multilayer Perceptron. The formed ...

Journal: :Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2001
C Cutler S Giri S Jeyapalan D Paniagua A Viswanathan J H Antin

PURPOSE Controversy exists as to whether the incidence of graft-versus-host disease (GVHD) is increased after peripheral-blood stem-cell transplantation (PBSCT) when compared with bone marrow transplantation (BMT). We performed a meta-analysis of all trials comparing the incidence of acute and chronic GVHD after PBSCT and BMT reported as of June, 2000. Secondary analyses examined relapse rates ...

Journal: :Turkish journal of haematology : official journal of Turkish Society of Haematology 2010
Hatice Şanlı Bengü Nisa Akay Ender Soydan Pelin Koçyiğit Mutlu Arat Osman İlhan

OBJECTIVE We aimed to evaluate the clinical features of sclerodermatous chronic graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (AHSCT). METHODS We retrospectively analyzed 423 patients who underwent AHSCT. We assessed age, sex, pre-transplant diagnosis, conditioning regimen, GVHD prophylaxis, and occurrence of acute GVHD (aGVHD), chronic lichenoid an...

Journal: :Blood 2008
Dongchang Zhao Chunyan Zhang Tangsheng Yi Chia-Lei Lin Ivan Todorov Fouad Kandeel Stephen Forman Defu Zeng

CD103 (alphaEbeta7) has been shown to be an excellent marker for identifying in vivo-activated FoxP3(+)CD4(+) regulatory T (Treg) cells. It is unknown whether reinfusion of in vivo-activated donor-type CD103(+) Treg cells from recipient can ameliorate ongoing chronic graft-versus-host disease (GVHD). Here, we showed that, in a chronic GVHD model of DBA/2 (H-2(d)) donor to BALB/c (H-2(d)) recipi...

Journal: :Revista da Associacao Medica Brasileira 2016
Vaneuza A M Funke Maria Claudia Rodrigues Moreira Afonso Celso Vigorito

graft-versus-host disease (GVHD) is one of the main complications of hematopoietic stem cell transplantation, affecting about 50% to 80% of the patients. Acute GVHD and its clinical manifestations are discussed in this article, as well as the new NIH criteria for the diagnosis and classification of chronic GVHD. Therapy for both chronic and acute GVHD is an important field of discussion, as the...

Journal: :The Journal of Experimental Medicine 1984
S T Pals H Gleichmann E Gleichmann

We studied the alloreactive properties of donor T cells obtained from F1 mice that had recovered from the allosuppression of acute graft-vs.-host disease (GVHD) and showed mild symptoms of chronic GVHD, i.e., so-called secondary chronic GVHD. To this end, we used (B10 x DBA/2)F1 mice that had been injected with 10(8) B10 spleen cells 100-150 d previously. Such GVHD F1 mice were repopulated by l...

2011
Byung-Sik Cho Nak-Gyun Chung

which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The role of B cells in acute graft-versus-host disease TO THE EDITOR: Mounting evidences implicates B cells in the pathogenesis of chronic graft-versus-host disease (GVHD). The body of evidence includes findings such as correlation between chronic GVHD and a...

2017
Hind Rafei Mohamed A. Kharfan-Dabaja Taiga Nishihori

Although significant advances have been made in the biologic understanding of graft-versus-host disease (GVHD) and its treatment options, GVHD remains the single most challenging obstacle to the success of allogeneic hematopoietic cell transplantation (HCT) due to high risk of disabling morbidity and mortality. Extracorporeal photopheresis (ECP) has promising effects in controlling steroid-refr...

2001
Emin Kansu Ted Gooley Mary E. D. Flowers Claudio Anasetti H. Joachim Deeg Richard A. Nash Jean E. Sanders Robert P. Witherspoon Frederick R. Appelbaum Rainer Storb Paul J. Martin

This study compared the incidence of clinical extensive chronic graft-versushost disease (GVHD), transplantationrelated mortality, survival, and relapsefree survival among recipients randomly assigned to receive a 24-month or a 6-month course of cyclosporine prophylaxis after transplantation of allogeneic marrow from an HLA-identical sibling or alternative donor. Patients who did not have clini...

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