Acute local toxicity refers to the local toxic effects that may result from a single exposure to a chemical or product, by way of the oral, dermal, ocular or inhalation routes. The exposure can be incidental, accidental or deliberate (for example, in the case of cosmetics and certain medicines). The dermal route of exposure can also be a significant route for entry into the systemic circulation...

Background & Aims: Dry type localized cutaneous Leishmaniasis due to Leishmania tropica is one of the most prevalent cutaneous parasitic infections in Kerman province. It seems that cellular immune response and the nature of immune inflammatory cells comprising the inflammatory background play a determinant role in this infection. Methods: Skin biopsies of 53 patients with acute(<2 years durati...

To date, special attention should be paid to drugs that have antimicrobial, anti-inflammatory and wound-healing effects, one of which is sodium-containing drugs.&#x0D; The article presents the results experimental studies study acute toxicity drugs: glycetinate 2 %, its analogues – ovocid 3 potassium-sodium 1.5% (Na/K 1.5 %). was carried out by applying skin animals. experiment used white rats ...

BACKGROUND Previously, we have reported that most, if not all, of the Scyphozoan jellyfish venoms contain multiple components of metalloproteinases, which apparently linked to the venom toxicity. Further, it is also well known that there is a positive correlation between the inflammatory reaction of dermal tissues and their tissue metalloproteinase activity. Based on these, the use of metallopr...

The mycotoxin, citrinin (CTN), is a contaminant of various food and feed materials. Several in vivo and in vitro studies have demonstrated that CTN has broad toxicity spectra; however, dermal toxicity is not known. In the present investigation, dermal exposure to CTN was undertaken to study oxidative stress, DNA damage, cell cycle arrest, and apoptosis in mouse skin. A single topical applicatio...

Exposure of the scrotal skin to a concentrated paraquat solution led to renal and respiratory failure and to hepatic damage with eventual recovery of the patient. Dermal exposure to paraquat, especially to the scrotum may produce serious systemic toxicity.

The acute oral and dermal toxicity of two new ethyl-carbamates (ethyl-4-bromophenyl-carbamate and ethyl-4-chlorophenyl-carbamate) with ixodicide activity was determined in rats. The oral LD50 of each carbamate was 300 to 2000 mg/kg, and the dermal LD50 of each carbamate was >5000 mg/kg. Clinically, the surviving rats that had received oral doses of each carbamate showed decreased weight gain (P...