In oocytes with nondisjoined chromosomes 21 due to a meiosis I (MI) error, recombination is significantly reduced along chromosome 21; several lines of evidence indicate that this contributes to the nondisjunction event. A pilot study found evidence that these oocytes also have reduced recombination genome-wide when compared with controls. This suggests that factors that act globally may be con...

background because of varying reports, there is still need to investigate the impact of wrestling on hematological indices. objectives we investigated differences in the basic hematological indices in wrestlers compared to sedentary controls. patients and methods the blood samples containing anticoagulant were collected from 12 male elite wrestlers (age = 24 ± 1.2 years, weight = 76 ± 5 kg) wit...

IL-5 is a Th2 cytokine which activates eosinophils and is suggested to have an atheroprotective role. Genetic variants in the IL5 locus have been associated with increased risk of CAD and ischemic stroke. In this study we aimed to identify genetic variants associated with IL-5 concentrations and apply a Mendelian randomisation approach to assess IL-5 levels for causal effect on intima-media thi...

Cytogenetic studies of 91 consecutive patients with therapy-related myelodysplasia or overt acute nonlymphocytic leukemia disclosed characteristic defects of chromosome 7 in 48 cases and of chromosome 5 in 21 cases. The chromosome 5 abnormalities were consistently present in all abnormal mitoses at the time of diagnosis, as were the chromosome 7 abnormalities in 45 of the 48 patients. Various a...

It is often convenient to define models for the process of chiasma formation at meiosis as stationary renewal models. However, count-location models are also useful, particularly to capture the biological requirement of at least one chiasma per chromosome. The Sturt model and truncated Poisson model are both count-location models with this feature. We show that the truncated Poisson model can a...

IHRONIC GRANULOCYTIC LEUKEMIA is characterized by hepatosplenomegaly, a markedly elevated white blood cell count with a spectrum of immature and mature granulocytic elements present, a proliferative granulocytic bone marrow, low levels or absence of leukocyte alkaline phosphatase activity and the presence of the Philadelphia chromosome.’ The patient to be described had chronic granulocytic leuk...

CASE STUDY A.B. is a 32-year-old Caucasian man with a significant, 12-year medical history of diabetes mellitus type I as well as a history of hypertension and hypercholesterolemia. He presented to his primary care doctor with blurred vision and was referred to a retinal specialist, who diagnosed hemorhagic and leukemic retinopathy resulting in limited vision. A complete blood count was drawn d...

conclusions this study revealed allele frequency of some strs on chromosome 12 and 16 for the first time in iran, and indicated differences between subjects with metabolic syndrome and subjects in the control group. results there was no significant deviation in allelic frequencies from hardy-weinberg equilibrium for all the studied markers except for d12s1632 and d12s329. the long alleles in d1...

UNLABELLED We describe a rare presentation of acute lymphoblastic leukemia in a young adult male who at the beginning of the disease lacked the Philadelphia chromosome in bone marrow and blood cells and fluorescence in situ hybridization was negative for the presence of a clone with the BCR-ABL1 rearrangement. The patient initially had pancytopenia with a blast cell count of 5% in the periphera...

in chronic myelogenous leukemia (cml), the mature granulocytes originate from a stem cell line harboring an abnormal chromosome, therefore it is possible that metabolic-functional abnormalities occur in the morphologically mature cells. in the present study, the phagocytic activity including intracellular killing, nitro blue tetrazolium (nbt) reduction, and phagocytosis were studied in 37 cml p...