Chromium supplements are thought to be the second most commonly taken nutritional supplement, used by an estimated 10 million Americans (1). Chromium is an essential element in humans, and deficiency is associated with the development of diabetes, which was first noted in patients receiving long-term parenteral nutrition before the advent of routine chromium supplementation (2,3). In these pati...

We report here the first orally active, selenium-based antihypertensive agent, and we demonstrate its restricted CNS permeability using inductively coupled plasma/mass spectroscopy (ICP/MS) and operant behavioral analysis. The biochemistry and pharmacology of selenium are subjects of intense current interest. As a consequence of the redox chemistry of the selenium moiety, phenylaminoalkyl selen...

Chromium is a naturally occurring, toxic heavy metal used in many industrial processes. The U.S. Department of Labor's Occupational Safety and Health Administration has established specific limits for occupational exposure levels of chromium and guidelines for medical surveillance of individuals who have been exposed to chromium. The author presents a case in which a 54-year-old man who had bee...

This study evaluated the toxicity of hexavalent and trivalent compounds of chromium to the pacu, Piaractus mesopotamicus, in acute exposures of 96 h through mortality and histopathological responses. Hexavalent potassium dichromate was more toxic than trivalent compounds of chromium chloride, chromium oxide and chromium carbochelate. Sufficient mortalities occurred only with potassium dichromat...

Many orthopaedic implants are composed of alloys containing chromium. Of particular relevance is the increasing number of Cobalt Chromium bearing arthroplasies being inserted into young patients with osteoarthritis. Such implants will release chromium ions. These patients will be exposed to the released chromium for over 50 years in some cases. The subsequent chromium ion metabolism and redistr...

chromium(III) up to 100 ng mL−1, and for chromium(VI) up to 200 ng mL−1) were obtained, using the “fixed time” method with detection limits of 4.9 ng mL−1 and 3.8 ng mL−1, respectively. The results suggest that at the reaction conditions chromium(VI) is reduced and chromium(III) is oxidized to an intermediate oxidation state and the catalytic action of chromium is due to the formation of an act...

OBJECTIVES Molecular epidemiological techniques, capable of detecting damage to DNA, were used to see if such damage occurred in the lymphocytes of a group of workers exposed to chromium. The two aims of this pilot study were to see if these new techniques might make useful biological monitoring tools for workers exposed to chromium and also, to help assess whether the current occupational expo...

Arsenic, chromium, and nickel are reported in several epidemiologic studies to be associated with lung cancer. However, the health effects of arsenic, chromium, and nickel exposures are equivocal for children. Therefore, we performed a cross-sectional study to investigate possible associations between the internal concentrations of arsenic, chromium, and nickel and the level of oxidative stress...

OBJECTIVES To compare the self reported health of a group of individuals living in an area contaminated by chromium (chromium group) with a group living in an uncontaminated area (control group), and to assess the effects of perception of risk from exposure to chromium on health. DESIGN Cross sectional study using the SF-36 validated quality of life questionnaire. Further questions were added...