Background: Choriocarcinoma is a rare, aggressive subtype of gestational trophoblastic neoplasia. The diagnosis of metastatic choriocarcinoma in the setting of a viable intrauterine pregnancy is exceedingly rare and often associated with feto-maternal hemorrhage. Case: An otherwise healthy Gravida 1 Para 0 at 34 weeks gestational age presented with metastatic choriocarcinoma and a viable fetus....

•We report a choriocarcinoma coexisting with an epithelioid trophoblastic tumor.•Chemotherapy with methotrexate, etoposide, and actinomycin-D was efficacious.•Choriocarcinoma with epithelioid trophoblastic tumor may benefit from chemotherapy.

BACKGROUND Choriocarcinoma syndrome is known as a lethal complication from tumoral hemorrhage, which frequently occurs at the site of tumor metastasis. CASE PRESENTATION A 59-year-old man with 60-pack-year smoking history was referred to our hospital because of hemoptysis. Chest computed tomography (CT) showed a 28 × 18 mm spiculated nodule with a cavity infiltrating the left upper lobe. A tr...

Choriocarcinoma is a pure epithelial tumor composed of syncytiotrophoblastic and cytotrophoblastic cells with common metastases to the lung, vagina, liver, kidney, and brain [1]. Metastasis to the breast is very rare [2]. Since choriocarcinoma is a rapidly invasive, widely metastasizing malignancy with good response to chemotherapy, it is important to obtain early diagnosis for better outcome [...

We report the development and characterization of an IRMA for the direct measurement of nicked human chorionic gonadotropin (hCGn) in blood and urine. hCGn derived from a reference preparation of hCG used as an immunogen elicits monoclonal antibodies (mAbs) with enhanced recognition of human luteinizing hormone epitopes. The most specific assay for pregnancy hCGn is an IRMA composed of one mAb ...

Intracerebral hemorrhage as initial presentation of nongestational choriocarcinoma is extremely rare. The therapy includes surgery, chemotherapy and radiotherapy. Nongestational metastatic choriocarcinoma has a poor treatment effect and a dismal prognosis. This study is to report a rare case of intracerebral hemorrhage as initial presentation of unknown primary of nongestational choriocarcinoma...

Gestational choriocarcinoma is a rare and aggressive type of gestational trophoblastic neoplasia, which is characterized by early vascular invasion and widespread metastases. Choriocarcinoma metastasizes hematogenously, and bleeding from metastases is common. Splenic rupture from a metastatic tumour is exceedingly rare, with only a few reports. We report a case of a 41-year-old female presentin...

BACKGROUND Human placental development resembles tumorigenesis, due to the invasive and fusogenic potential of trophoblasts. However, these features are tightly controlled in trophoblasts. Disturbance of this spatial and temporal regulation is thought to contribute to the rare formation of choriocarcinomas. Promoter hypermethylation and loss of the tumor suppressor Retinoic acid receptor respon...