Head and neck sarcomas are a rare and heterogeneous group of tumors that pose management challenges. We report our experience with these tumors. Forty consecutive patients treated for 44 head and neck sarcomas between 1997 and 2014 were culled from our prospectively maintained head and neck database. Five patients were excluded. The adult cohort consisted 29 (83%) patients of a mean age of 57.7...

Gliosarcoma is a rare tumor of the central nervous system characterized by a biphasic histological pattern. Our objective is to describe clinical, morphological and immunohistochemical features of two cases of gliosarcoma with chondroblastic osteosarcomatous differentiation and to discuss its pathogenetic mechanisms. CASE 1: A 52- year-old male patient underwent parietal craniotomy due to anapl...

OBJECTIVES To determine the clinicopathological features of osteogenic sarcomas of the mandible and maxilla. MATERIALS AND METHODS A retrospective study was carried out on all osteosarcoma from the jaw diagnosed in the Stomatology Unit, Institute for Medical Research, Kuala Lumpur from 1967 to 2008. All data regarding the age at presentation, gender, race, clinical presentation, radiographica...

Osteocalcin is one of the most abundant noncollagenous proteins found in adult bone. It is a highly conserved gamma-carboxyglutamic acid-containing protein that is believed to be produced exclusively by osteoblasts. In this study, intracellular and extracellular localization of osteocalcin in osteosarcoma was examined with anti-osteocalcin antibody and in situ hybridization using a synthetic ol...

Pregnancy is a physiological period in a woman’s life. It is well known that some pathological changes have been reported to be more common in pregnancy than other stages of the life. It seems that primary tumors have a tendency to progress more rapidly in pregnancy due to hormonal alterations or increased expression of some growth factors. The exact relationship between pregnancy and malignanc...

Chondrosarcoma is a malignant tumor characterized by the proliferation of chondroblasts producing no bone , which can sometimes developed by metaplasia inside a connective tissue and present a rapid growth of both cartilaginous and connective tissues. Chondrosarcoma is a very rare tumor, two times less frequent than osteosarcoma. It may represent 11-20% of all malignant bone tumors as reported ...

Pycnodysostosis is a rare sclerosing bone dystrophy. The main clinical features are short stature and oral and maxillofacial abnormalities such as a large head, a small and underdeveloped face with prominent nose and eyes, irregular dentition, small hands and feet with dystrophic nails, and trunk deformities such as scoliosis. The differential diagnosis is established with other skeletal dyspla...

Objectives In order to assess clinical behavior, response to treatment, and factors influencing prognosis of Korean patients with osteosarcoma of the jaws (OSJ). Materials and Methods A retrospective study of clinical, and pathological records of 26 patients with OSJ treated at the Department of Oral and Maxillofacial Surgery in Yonsei University Dental Hospital from 1990 to March 2017. Res...