نتایج جستجو برای: cholecystokinin antagonist

تعداد نتایج: 61860  

Journal: :Cancer research 1993
T Sethi T Herget S V Wu J H Walsh E Rozengurt

Gastrin, cholecystokinin (CCK), and CCK-related peptides comprise a hormonal family characterized by an identical carboxy-terminal amino acid sequence, a domain critical for receptor binding. The addition of gastrin to small cell lung cancer (SCLC) cells causes a rapid and transient increase in the intracellular concentration of calcium ([Ca2+]i). Furthermore, gastrin acts as a direct growth fa...

Journal: :Molecular pharmacology 2015
Maoqing Dong Ashton M Vattelana Polo C-H Lam Andrew J Orry Ruben Abagyan Arthur Christopoulos Patrick M Sexton David R Haines Laurence J Miller

Understanding the molecular basis of ligand binding to receptors provides insights useful for rational drug design. This work describes development of a new antagonist radioligand of the type 1 cholecystokinin receptor (CCK1R), (2-fluorophenyl)-2,3-dihydro-3-[(3-isoquinolinylcarbonyl)amino]-6-methoxy-2-oxo-l-H-indole-3-propanoate (T-0632), and exploration of the molecular basis of its binding. ...

Journal: :The Journal of pharmacology and experimental therapeutics 2004
Hsiang-En Wu Jonathan Thompson Han-Sen Sun Randy J Leitermann James M Fujimoto Leon F Tseng

Intrathecal (i.t.) pretreatment with a low dose (0.3 nmol) of morphine causes an attenuation of i.t. morphine-produced analgesia; the phenomenon has been defined as morphine-induced antianalgesia. The opioid-produced analgesia was measured with the tail-flick (TF) test in male CD-1 mice. Intrathecal pretreatment with low dose (0.3 nmol) of morphine time dependently attenuated i.t. morphine-prod...

Journal: :Life sciences 1997
E Rodríguez-Martín I Alvaro-Alonso G Bodega E Arilla

The mechanism whereby somatostatin (SS) produces beneficial effects in established pancreatitis induced by pancreaticobiliary duct ligation (PBDL) is still not clear. The aim of the work was to evaluate the possibility of a direct action of SS on pancreatic acinar cells from rats with acute pancreatitis. For this purpose, we studied the SS-receptor-adenylate cyclase system in pancreatic acinar ...

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