We studied the effect of chlorpromazine on fluid accumulation caused by purified heat-stable enterotoxin (ST) from enterotoxigenic Escherichia coli in suckling mice. We found that chlorpromazine inactivated ST itself in vitro, but did not inhibit the activity of ST in the intestines.

A fatal case of agranulocytosis due to chlorpromazine is reported. Mechanisms other than immunological are generally believed to be responsible for chlorpromazine-induced agranulocytosis. However, the demonstration of a drug-specific leuco-agglutinin in the serum of this patient suggests that an immunological mechanism was responsible for the agranulocytosis.

When tested as a microbial model for mammalian drug metabolism, the filamentous fungus Cunninghamella elegans metabolized chlorpromazine and methdilazine within 72 h. The metabolites were extracted by chloroform, separated by high-performance liquid chromatography, and characterized by proton nuclear magnetic resonance, mass, and UV spectroscopic analyses. The major metabolites of chlorpromazin...

The effect of phenothiazines (trifluoperazine and chlorpromazine) on cholesteryl ester metabolism has been investigated in J 774 mouse monocyte-macrophages. The incorporation of oleic acid into cholesteryl ester and the activity of acylcoenzyme A: cholesterol-O-acyltransferase were strongly decreased in cells pretreated for 24 h with trifluoperazine or chlorpromazine. Furthermore, trifluoperazi...

PURPOSE: To analyze the influence of chlorpromazine on renal histology of rats submitted to ischemia and reperfusion injury. METHODS: Sixteen Wistar rats - split in two groups - have been used: control group, receiving 3 mg/kg isotonic saline solution through caudal vein, and, the chlorpromazine group, receiving 3 mg/kg-IV of such medication. The nephrectomy of the left kidney lower third was...

Superoxide production by granulocytes is a result of the activation of an NAD(P)H-dependent oxidase present in the plasma membrane. Chlorpromazine (5-50 muM) prolongs the time necessary to activation of the superoxide generating system and inhibits the extent of activation. When chlorpromazine is added after activation, there is an inhibition of further superoxide production. These effects are ...

Lung contains both Mg2+-dependent and Mg2+-independent phosphatidate phosphohydrolase activities. Addition of Triton X-100 (0.5%) or chlorpromazine (1 mM) leads to a marked increase in the total phosphatidate phosphohydrolase activity in rat lung microsomes (microsomal fractions), but a decrease in the Mg2+-dependent activity. These observations suggest that the Mg2+-independent activity is sti...

Investigations by Courvoisier, Fournel, Ducrot, Kolsky, and Koetschet in 1953 had shown that chlorpromazine reduces convulsions in mice after coramine and in rabbits after nicotine Therefore, the drug seemed to suggest itself as an anticonvulsant in epilepsy But in 1954 Bente and Itil, De Castro and Brard, and Mayr and Lechner observed activation of the electroencephalogram (E.E.G.) in epilepsy...

The surface activity of triflupromazine, chlorpromazine, promazine, promethazine, and chlorpromazine sulfoxide has been determined at the air-solution interface by the drop-volume method to measure surface tension. Differences in the abilities of the various phenothiazines employed to affect surface pressure development seem correlated with their relative nonpolarities. Anionic buffer ingredien...

Priapism is a prolonged and usually painful erection which is not associated with the sexual desire. It is an uncommon urologic emergency with variety of known etiologies such as the use of psychotropic medications. Priapism under concurrent treatment with chlorpromazine and risperidone has not been reported so far. Herein, a psychotic patient who developed priapism during chlorpromazine and ri...