OBJECTIVE The objective of the research was to formulate and evaluate sumatriptan succinate-loaded chitosan nanoparticles for migraine therapy in order to improve its therapeutic effect and reduce dosing frequency. MATERIAL AND METHODS The Taguchi method design of experiments (L9 orthogonal array) was applied to obtain the optimized formulation. The sumatriptan succinate-loaded chitosan nanop...

Reverse microemulsion was used as a template to fabricate chitosan-alginate core-shell nanoparticles encapsulated with enhanced green fluorescent protein (EGFP)-encoded plasmids. The average size of DNA-entrapped nanoparticles measured by dynamic light scattering was increased proportionally, with the N/P ratios ranging from 5 to 20. These alginate-coated chitosan nanoparticles endocytosed by N...

Controlling microbial growth is crucial for many biomedical, pharmaceutical and food industry applications. In this paper, we used a femtosecond laser to microstructure the surface of chitosan, a biocompatible polymer that has been explored for applications ranging from antimicrobial action to drug delivery. The influence of energy density on the features produced on chitosan was investigated b...

The phenylboronic acid-conjugated chitosan nanoparticles were prepared by particle surface modification. The size, zeta potential and morphology of the nanoparticles were characterized by dynamic light scattering, zeta potential measurement and transmission electron microscopy. The cellular uptake, tumor penetration, biodistribution and antitumor activity of the nanoparticles were evaluated by ...

Purpose Escherichia coli O157:H7 is one of the most important pathogens which create hemorrhagic colitis and hemolytic uremic syndrome in human. It is one of the most prevalent causes of diarrhea leading to death of many people every year. The first diagnosed gene in the locus of enterocyte effacement pathogenicity island is eae gene. The product of this gene is a binding protein called intimin...

in this paper, fe3o4-chitosan nanoparticles were prepared by the immobilization of chitosan on the surface of fe3o4 nanoparticles. then, the 5-substituted hydantoins were synthesized from the condensation of aldehyde derivatives, ammonium carbonate and zinc cyanide as a well-known cyanating agent by the magnetic fe3o4-chitosan nanoparticles under neat conditions. fe3o4-chitosan nanocatalyst as ...

Background: Pseudomonas aeruginosa biofilm is one of the problems in antibiotic treatment infections. Nanomedicines, such as chitosan (CS) can carry multiple drugs and improve therapeutic effects antibiotics. Objectives: This study aimed at synthesis characterization ciprofloxacin-loaded nanoparticles for eradication P. aeroginosa biofilm. Methods: Cipro-CS microparticles were prepared by ionic...

BACKGROUND Bacterial biofilms formed on the root canal wall are often difficult to remove. This study aimed to evaluate the cytotoxic effect and antibacterial efficacy of chitosan when used as root canal irrigant against E. Faecalis and Candida albicans biofilm formed on tooth substrate. MATERIAL AND METHODS The present study evaluated antibacterial effect of 0.25% Chitosan, 0.5% Chitosan, 2%...

The focus of this review is to provide an overview of the chitosan based nanoparticles for various non-parenteral applications and also to put a spotlight on current research including sustained release and mucoadhesive chitosan dosage forms. Chitosan is a biodegradable, biocompatible polymer regarded as safe for human dietary use and approved for wound dressing applications. Chitosan has been ...

Chitosan is a cationic polysaccharide usually obtained by alkaline deacetylation of chitin 13 poly(N-acetylglucosamine). It is biocompatible, biodegradable, mucoadhesive and non-toxic. These 14 excellent biological properties make chitosan a good candidate as platform for developing drug 15 delivery systems with improved biodistribution, increased specificity and sensitivity, and reduced 16 pha...