Crystallization of a solution with high enantiomeric excess can generate a mixture of crystals of the desired enantiomer and the racemic compound. Using a mixture of S-/RS-ibuprofen crystals as a model, we demonstrated that magnetic levitation (MagLev) is a useful technique for analysis, separation and enantioenrichment of chiral/racemic products.

It was serendipitously observed that cis-[PtCl2(NCEt)PPh3] reacted differently with either racemic or enantiopure 4-aza[6]helicene, giving respectively cis (racemic) and trans (enantiopure) [Pt(II)Cl2(4-aza[6]helicene)PPh3] complexes. This unexpected reactivity is explained through a dynamic process (crystallization-induced diastereoselective transformation) and enables a new aspect of reactivi...

Whereas the determination of high enantiomeric fractions (EF) of chiral compounds is very well established, the accurate determination of small deviations from racemic compositions has not yet received much attention despite its relevance to studies dealing with the origin of homochirality, where only small initial enantiomeric bias is expected. Racemic samples of representative a-amino acids w...

Recently it was shown that smectic liquid crystal phases formed by achiral banana-shaped molecules are chiral. Films of such phases generally contain both homochiral (consisting of layers of the same chirality) and racemic (the chirality alternates in subsequent layers) domains. So far it has not been clear how to control the overall chirality of the sample. By observing the effects of the appl...

Rand S-propylene oxide (PO) have been shown to interact enantiospecifically with the chiral surfaces of Au nanopar‐ ticles (NPs) modified with Dor L-cysteine (cys). This enantiospecific interaction has been detected using optical polarimetry measurements made on solutions of the Dor L-cys modified Au (cys/Au) NPs during addition of racemic PO. The selective adsorption of one enantiomer of the P...

BACKGROUND African Americans have higher tobacco-related morbidity and mortality and are more likely to smoke menthol cigarettes than their white counterparts. This study examined differences between African American menthol and non-menthol smokers in smoking characteristics and cessation. METHODS The study sample consisted of 600 African American smokers enrolled in a clinical trial that ass...

Resolution of racemic tert-butyl-1-(2-methylnaphthyl)-phosphine oxide 1, a chiral phosphorus compound, was achieved using selectors developed from a small peptide library. Separation factors as high as 3.2 were observed. The library consists of 81 peptide-based potential chiral selectors on polymeric synthesis resins. The linker needed to immobilize the identified chiral selectors onto silica g...

Racemic omega-substituted caprolactones can be completely converted into chiral polyesters of remarkable MW and high ee by combining lipase-catalyzed ring-opening polymerization with Ru-catalyzed racemization.

The transfer and dynamic fixation of chirality in cyclic azobenzenes using R-(+)-1-phenylethylalcohol (R-PEA) and S-(-)-1-phenylethylalcohol (S-PEA) as solvents or additives are investigated. The cyclic azobenzenes used in this study carry a 1,5-dioxynaphthalene moiety as rotating unit, connected to the photoisomerizing (E-Z) azobenzene unit with spacers of varying lengths. With suitable length...