Cancer treatment often tends to involve direct targeting enzymes essential for the growth and proliferation of cancer cells. The aim of this study was the recognition of the possible role of selected protein kinases: PI3K, ERK1/2, and mTOR in cell proliferation and cell cycle in malignant melanoma. We investigated the role of protein kinase inhibitors: U0126 (ERK1/2), LY294002 (PI3K), rapamycin...

Decreased heart rate variability (HRV) is a major risk factor for sudden death and cardiovascular disease. We previously demonstrated that parasympathetic dysfunction in the heart of the Akita type 1 diabetic mouse was due to a decrease in the level of the sterol response element-binding protein (SREBP-1). Here we demonstrate that hyperactivity of glycogen synthase kinase-3β (GSK3β) in the atri...

Background: In this study 11 height and diameter prediction models were fitted evaluated for Himalayan Chir pine (Pinus roxburghii) in Jammu region of UT J K (India). The data collected from 50 permanent sample plots uneven aged stands Pinus roxburghii total 500 individual tree measurement used study. At initial stage all the resulted significant coefficients, besides various selection criteria...

CHEST, 71: 3, MARCH, 1977 blood vessels from alveoli to mediastinum. Arch Intern Med 64:913-926, 1939 3 MackIln NIT, Macklin CC: Malignant interstitial emphysema of the lungs and mediastinum as an important occult complication in many respiratory diseases and other conditions: An interpretation of the clinical literature in the light of laboratory experiment. Medicine 23:281-357, 1944 4 Sheinfe...

Adams, J. C. (1958). Outline of Fractures, Including 7oint Injuries, 2nd ed., p. 70. Livingstone, Edinburgh. Brickner, Wm., and Milch, H. (1926). International Clinics, 36, 1, 216. Gaston, S. R., Smith, F. M., and Baab, 0. D. (1949). Amer. 7. Surg., 78, 631. Metcalfe, R. F. (1926). Surg. Gynec. Obstet., 34, 270. Patrick, J. (1940). Brit. 7. Surg., 27, 108, 737. Smillie, I. S. (1962). Injuries o...

The intramolecular condensation of ortho substituents triaryl carbenium ions can lead to the formation cationic helicenes. These chiral and configurationally stable molecules exhibit extended optical properties reminiscent their parent methylium ions. Among them, [6]helicenes are particularly interesting as orthogonal late-stage functionalization strategies allow introduction a variety auxochro...

An appraisal of butterfly species composition in terms comparative diversity richness various habitat types was conducted and around the Nandhour Wildlife Sanctuary Terai Arc landscape Uttarakhand. During two years survey period (March 2018–February 2020), a total 89 butterflies belonging to families Nymphalidae 43 species, Pieridae 15 Lycaenidae 13 Hesperiidae eight Papilionidae seven Riodinid...

CHEST, 71: 3, MARCH, 1977 blood vessels from alveoli to mediastinum. Arch Intern Med 64:913-926, 1939 3 MackIln NIT, Macklin CC: Malignant interstitial emphysema of the lungs and mediastinum as an important occult complication in many respiratory diseases and other conditions: An interpretation of the clinical literature in the light of laboratory experiment. Medicine 23:281-357, 1944 4 Sheinfe...