there are few reports concerning interferon induced myocardial dysfunction. a known case of multiple myeloma who was receiving interferon alpha (ifa) for 14 months was brought to the emergency room in frank: pulmonary edema. after treatment of heart failure and discontinuation of interferon alpha, he remained asymptomatic thereafter. another case of chronic active hepatitis on ifa complained of...

An unusual case of primary cardiac lymphoma presenting as restrictive cardiomyopathy with arrhythmia is reported in a 72-year-old woman who was admitted for evaluation of exertional dyspnea and palpitations. Electrocardiography (ECG) showed atrioventricular dissociation and right heart cardiac catheterization revealed a typical 'dip-and-plateau' waveform. Restrictive cardiomyopathy was suspecte...

Abstract Introduction Cardiovascular disease has become the leading cause of mortality among breast cancer survivors. Patients with who receive treatment anthracycline and trastuzumab therapies are at risk for development non-ischemic cardiomyopathy. The heart failure during chemotherapy administration often results in interruption these life saving therapies. Purpose We aim to investigate whet...

INTRODUCTION Newly developed antineoplastic drugs have resulted in improvements in morbidity and mortality from many forms of cancers. However, some of these new chemotherapeutic agents have potentially lethal side effects, which are now being exposed with their widespread use. Gemcitabine is a nucleoside analog, which is a commonly used agent for various solid organ malignancies. Phase 1 and 2...

The aim of the study was to evaluate the clinical usefulness of N-terminal pro-brain natriuretic peptide (NT-Pro BNP) and nitric oxide (NO) with echocardiography (gold standard test) in diagnosis of canine cardiomyopathy. Out of 374 cases, 82 cases showing cardiovascular abnormalities including 16 cases of cardiomyopathy were further selected for standardization of biomarkers. Significant (P

Preclinical and clinical studies suggest that anthracycline-induced cardiotoxicity can be prevented by administering coenzyme Q10 during cancer chemotherapy that includes drugs such as doxorubicin and daunorubicin. Studies further suggest that coenzyme Q10 does not interfere with the antineoplastic action of anthracyclines and might even enhance their anticancer effects. Preventing cardiotoxici...

Since the modern era of cancer chemotherapy that began in the mid-1940s, survival rates for children afflicted with cancer have steadily improved from 10% to current rates that approach 80% (60). Unfortunately, many long-term survivors of pediatric cancer develop chemotherapy-related health effects; 25% are afflicted with a severe or life-threatening medical condition, with cardiovascular disea...

As the geriatric population is growing, it is increasingly important to be familiar with chemotherapy for the elderly. Age-related changes in pharmacokinetics are documented for doxorubicin, etoposide, ifosfamide, daunorubicin, mitomycin, cisplatin and methotrexate. The hematological toxicity of most standard-dose chemotherapy is not affected by age in patients with normal organic functions and...

Anthracyclines such as doxorubicin are highly effective chemotherapy agents used to treat many common malignancies. However, their use is limited by cardiotoxicity. We previously identified visnagin as protecting against doxorubicin toxicity in cardiac but not tumor cells. In this study, we sought to develop more potent visnagin analogs in order to use these analogs as tools to clarify the mech...

Abstract Introduction Dilated cardiomyopathy (DCM) is a condition whose etiologies may be various. DCM with ventricular disfunction frequent complication of chemotherapy. Peripartum characterized by reduced ejection fraction (EF), presenting toward the end pregnancy or in first months after delivery. Lipodystrophy associated to dilated and hypertrophic cardiomyopathy. Material Methods A 28-year...