Nervous chemokines uidance molecules from the immune and nervous systems are getting mixed up in each others business. have found that a leukocyte attractant called stromal-derived factor 1 (SDF-1) is the main factor that entices embryonic cerebellar neurons to their correct location. SDF-1 is a chemokine—a peptide that attracts leukocytes by activating a G protein signaling cascade. In contras...

Chronic obstructive pulmonary disease (COPD) is characterized with the chronic airway inflammation associated with progressive obstruction of airflow. Airway epithelial cells play an essential role of development in COPD. Chemokines as extracellular signaling proteins have been suggested to be involved in the inflammatory process of COPD. The present review summarized the variation of chemokine...

The expression of distinct chemokines within the asthmatic lung suggests that specific regulatory mechanisms may mediate various stages of asthmatic disease. Global transcript expression profiling was used to define the spectrum and kinetics of chemokine involvement in an experimental murine model of asthma. Seventeen chemokines were induced in the lungs of allergen-inoculated mice, as compared...

chemokines are biologically active peptides involved in the pathogenesis of various pathologies including brain malignancies. they are amongst primitive regulators of the development of immune responses against malignant glial tumors. the present study aimed to examine the expression of cc chemokines in anaplastic astrocytoma and glioblastoma multiform patients at both mrna and protein levels. ...

C hemokines (chemotactic cytokines) are small (7–10 kDa) heparin binding proteins that govern the migration of circulating leucocytes to the sites of inflammation. Chemokines, currently numbering more than 50, are classified into four supergene families based on cysteine residues: CXC, CC, C, and CX3C chemokines (table 1). Chemokines are distinguished from other cytokines by acting on the G pro...

BACKGROUND Respiratory syncytial virus (RSV) bronchiolitis in infants is characterized by a massive neutrophilic infiltrate into the airways. Chemokines direct migration of leukocytes and contribute to the pathogenesis of RSV disease. However, little is known about pulmonary chemokine responses to RSV in humans. Our aim was to characterize the production of chemokines in the lungs of infants wi...

objective(s): the impact of fasting in ramadan as a unique type of nutritional regimen on biochemical and hematological parameters is still an issue of debate. almost very little is known regarding the regulatory role(s) of this nutritional status on immune responses or inflammation.   materials and methods:   the levels of biochemical parameters were determined using commercial diagnostic kits...

Viral myocarditis is a common cardiovascular disease, which has greatly threatened human health. However, up to now, the pathogenesis of viral myocarditis has been unclear, which leads to the lack of its effective treatments. To investigate the role of chemokines in pathogenesis of viral myocarditis, mRNA expression for a panel of 19 chemokines detected by RT-PCR in myocardial tissue of BALB/c ...