Introduction – Distinction between viable and non-viable myocardium is essential for diagnosis and treatment of patients with coronary artery disease. Delayed contrast-enhanced (DCE) MRI has become the gold standard to determine the size of chronic infarcts. However, although T2-weigthed MRI shows great promise to delineate the area at risk after the event related to the formation of edema, the...

BACKGROUND AND PURPOSE Pick complex (PC) is the name given to a group of diseases comprising Pick disease and its variations, all of which have a large degree of pathologic and clinical overlap. Because of this overlap, the observation of neuropathologic changes in vivo is difficult, although these changes play important roles in the criteria used for classification. The purpose of this study w...

In vivo chemical shift-compensated MR thermometry Pooja Gaur, Beat Werner, Pejman Ghanouni, Rachelle Bitton, Kim Butts Pauly, and William A Grissom Chemical and Physical Biology, Vanderbilt University, Nashville, TN, United States, Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States, Center for MR-Research, University Children's Hospital, Zurich, Switzerland, Radio...

The light-sensitive Belousov-Zhabotinsky (BZ) reaction with a ruthenium-based catalyst is a convenient system to study the effect of external perturbations on dynamical behavior of chemical reactions. The Ru(bpy)3Cl2 complex was first suggested as a luminescent indicator for the BZ reaction by Demas and Diemente.1 Later the reaction was found to be sensitive to visible light by Gaspar et al.,2 ...

Nuclear magnetic shielding is a second-order molecular electronic property which provides a severe test of the accuracy of molecular quantum mechanical calculations. While electric dipole polarizability and hyperpolarizabilities provide tests of the wavefunction at the outer regions, nuclear shielding is very sensitive, especially to contributions from high angular momentum functions, in the re...

The principal values of the 13C chemical-shift tensors of natural abundance biphenylene were measured at room temperature with the FIREMAT experiment. Of 18 crystallographically distinct positions (three sets of six congruent carbons each), the three primary bands have been resolved into seven single peaks and four degenerate peaks (two double, one triple, and one quadruple). Hence, eleven diff...

Nuclear magnetic resonance (NMR) spectroscopy is one of the techniques used in structural biology and drug discovery. A critical step in analysis of NMR images lies in automation of assigning NMR signals to nuclei in studied macromolecules. This procedure is known as sequence-specific resonance assignment and is carried out manually. Manual analysis of NMR data results in high costs, lengthy an...

A fast chemical-shift imaging using the gradient-echo technique is proposed for the separation of the water and fat in human in vivo imaging. This technique also incorporates magnetic field inhomogeneity correction in the fast chemical-shift imaging. Experimental results of the proposed imaging technique demonstrate that the method would be useful for quick in vivo water-fat separation imaging ...

Frataxin is the protein responsible for the genetically-inherited neurodegenerative disease Friedreich's ataxia caused by partial silencing of the protein and loss of function. Although the frataxin function is not yet entirely clear, it has been associated to the machine that builds iron-sulfur clusters, essential prosthetic groups involved in several processes and is strongly conserved in org...

NMR chemical shifts provide important local structural information for proteins. Consistent structure generation from NMR chemical shift data has recently become feasible for proteins with sizes of up to 130 residues, and such structures are of a quality comparable to those obtained with the standard NMR protocol. This study investigates the influence of the completeness of chemical shift assig...