Small molecule cholinesterase (ChE) inhibitors represent one of themost effective therapeutic strategies for the treatment of Alzheimer's disease (AD). However, only three of these drugs have entered the market. Understanding of the structures of successful ChE inhibitors is still very limited; therefore, it is an urgent task to identify new scaffolds for the design of ChE inhibitors. In the pr...

Sunto. – In questo lavoro si generalizzano alcuni risultati di [3] riguardanti la proprieta’ di alcune curve nodali, su superficie non-singolari in Pr, di essere ”geometricamente linearmente normali” (concetto che estende la ben nota proprieta’ di essere linearmente normale). Precisamente, per una data curva C, irriducibile e dotata di soli punti nodali come uniche singolarita’, che giace su un...

    Background: One of the main goals of health systems is to protect people against financial risks associated with diseases that can be catastrophic for patients. In 2014, Health Sector Evolution Plan (HSEP) was implemented in Iran; one of the objectives of HSEP was to reduce out-of-pocket payments and provide more financial protection for people. Therefore, the present study a...

Background: During the last two decades, significant advances have been made in the fields of lactococcal genetics and protein expression. Lactococcus lactis (L. lactis) is an effective vector for protein expression and can be used as an antigen delivery system. Hence, L. lactis is an ideal candidate for mucosal immunotherapy. Profilin (Che a 2), the major allergen in Chenopodium album, is one ...

In B. subtilis swarming and robust swimming motility require the positive trigger of SwrA on fla/che operon expression. Despite having an essential and specific activity, how SwrA executes this task has remained elusive thus far. We demonstrate here that SwrA acts at the main σ(A)-dependent fla/che promoter PA(fla/che) through DegU. Electrophoretic mobility shift assays (EMSA) reveal that SwrA ...

In questo lavoro viene proposta una estensione del linguaggio datalog [CP97]. datalog è un linguaggio logico basato su datalog, la cui innovazione sostanziale consiste nell’aumento della potenza espressiva, tramite l’introduzione di una semantica basata sulla circoscrizione, un meccanismo deduttivo non monotòno che generalizza l’ipotesi di mondo chiuso. Questo tipo di semantica fornisce interes...

L ife hisrory research represenrs one of rhe many merhodologies rhar fall under che moce general rubric of qualiracive research. Specifically, life hisrory and narracive analysis involve che use of discourse ro scudy human performance. This research merhod provides a rich descripcion of a person's represenracion of meaningful experiences and evems. The major source of dara is rhe inrerview, whi...

Peach harvest workers were evaluated for exposure to azinphosmethyl residues by measuring foliar residues, urinary alkyl phosphate metabolites, plasma and erythrocyte (RBC) cholinesterase (ChE), and dermal residues using clothing and skin washes. Workers entered orchards 51 days after application and worked in treated fields for ten of the next 17 days. Dislodgeable foliar residues ranged from ...

Sommario Nei sistemi P2P un serio problema che ne limita la scalabilità è l’esplosione di traffico dovuto al fatto che ogni peer propaga le query a tutto l’insieme dei peer ad esso noti. In questo lavoro affrontiamo tale problema proponendo una strategia per ridurre il numero di peer a cui propagare le query selezionando quei peer verso i quali l’aspettativa è alta. L’innovatività della propost...

Diblock copolymer nanoparticles encapsulating a paclitaxel prodrug, Propac 7, have been used to demonstrate the usefulness of a nonmetabolizable radioactive marker, cholesteryl hexadecyl ether (CHE), to evaluate nanoparticle formulation variables. Since CHE did not exchange out of the nanoparticles, the rate of clearance of the CHE could be used as an indicator of nanoparticle stability in vivo...